摘要
目的观察比较透明质酸钠联合倍他米松治疗膝骨类风湿关节炎的临床治疗疗效。方法选择2016年4月至2018年12月收治的100例膝骨类风湿关节炎患者进行研究,随机均分为对照组和实验组,各50例。对照组在关节腔内注射透明质酸钠2ml,实验组在关节腔内注射透明质酸钠2ml联合复方倍他米松1ml。比较两组患者的治疗效果、关节液中关节炎症介质[白细胞介素1(IL-1)、金属基质蛋白酶9(MMP-9)]含量及不良反应。结果实验组总有效率为98.00%,明显高于对照组的82.00%(P<0.05);治疗后,实验组关节炎介质IL-1含量和MMP-9含量均明显低于对照组(P<0.05);两组不良反应比较差异无统计学意义。结论透明质酸钠联合复方倍他米松关节腔注射治疗膝骨性关节炎,疗效显著,且安全可靠,值得临床上应用及推广。
Objective To observe and compare the clinical efficacy of sodium hyaluronate combined with betamethasone in the treatment of knee osteoarthritis. Methods 100 patients with knee osteoarthritis from April 2016 to December 2018 were randomly divided into control group and experimental group, with 50 cases in each group. The control group was injected with sodium hyaluronate 2 ml in the articular cavity, and the experimental group was injected with sodium hyaluronate 2 ml combined with compound betamethasone 1 ml in the articular cavity. The therapeutic effect, the levels of interleukin-1 (IL-1) and matrix metalloproteinase-9 (MMP-9) in synovial fluid and the adverse reactions were compared between the two groups. Results The total effective rate of the experimental group was 98.00%, which was significantly higher than that of the control group (82.00%, P< 0.05). After treatment, the levels of IL-1 and MMP-9 in the experimental group were significantly lower than those in the control group (P<0.05). There was no significant difference in adverse reactions between the two groups. Conclusion Sodium hyaluronate combined with compound betamethasone intra-articular injection is effective, safe and reliable in the treatment of knee osteoarthritis, which is worthy of clinical application and promotion.
作者
李俊
张徐明
吴頔
Li Jun;Zhang Xuming;Wu Di(Department of Physiotherapy and Acupuncture, Jiujiang NO.1 People' s Hospital, Jiujiang, Jiangxi, 332000, China;Department of Rheumatism Immunology, Jiujiang NO.1 People' s Hospital, Jiujiang, Jiangxi, 332000, China)
出处
《当代医学》
2019年第30期20-21,共2页
Contemporary Medicine
基金
江西省卫生健康委员会科技计划项目(20197110)
关键词
透明质酸钠
倍他米松
类风湿关节炎
炎症介质
疗效
Sodium hyaluronate
Betamethasone
Rheumatoid arthritis
Inflammatory mediators
Efficacy
