摘要
目的探讨功能性消化不良采用曲美布汀联合复方阿嗪米特治疗的症状转归。方法选择2017年1月-2018年12月期间该院收治的76例功能性消化不良患者,随机分为对照组和观察组,各38例。对照组采用复方阿嗪米特治疗,观察组在对照组基础上增加曲美布汀治疗,对比两组临床疗效、症状转归及用药安全性。结果观察组(97.37%)和对照组(81.58%)功能性消化不良治疗总有效率比较,差异有统计学意义(χ2=4.239,P=0.023)。观察组治疗后功能性消化不良症状积分(3.58±1.73)分及症状转归时间(21.82±8.23)d均显著低于对照组(5.34±1.81)分、(28.34±7.6)d,差异有统计学意义(t=14.172,P=0.021;t=13.518,P=0.022)。观察组曲美布汀+复方阿嗪米特治疗后不良反应发生率(2.63%)与对照组单纯复方阿嗪米特治疗(0.00%)比较,差异无统计学意义(χ2=3.186,P=0.698)。结论曲美布汀+复方阿嗪米特治疗功能性消化不良临床疗效可靠,有助于缩短症状转归时间,值得推广借鉴。
Objective To investigate the symptoms and prognosis of functional dyspepsia treated with trimebutine combined with compound azintamide. Methods A total of 76 patients with functional dyspepsia admitted to our hospital from January 2017 to December 2018 were selected. They were randomly divided into the control group and the observation group, with 38 cases in each group. The control group was treated with compound azintamide, while the observation group was treated with trimebutine on the basis of the control group. The clinical efficacy, prognosis and drug safety of the two groups were compared. Results The total effective rate of functional dyspepsia in the observation group(97.37%) was significantly higher than that in the control group(81.58%). And the difference was statistically significant(χ2=4.239,P=0.023). The score of functional dyspepsia symptoms(3.58±1.73)points and the time of symptom prognosis(21.82±8.23)d in the observation group were significantly lower than those in the control group(5.34±1.81)points,(28.34±7.69)d, with statistical significance(t=14.172,P=0.021;t=13.518,P=0.022). There was no significant difference in the incidence of adverse reactions between the observation group(2.63%) and the control group(0.00%)(χ2=3.186,P=0.698). Conclusion Trimebutine combined with compound azintamide has reliable clinical efficacy in the treatment of functional dyspepsia, which is helpful to shorten the prognosis time of symptoms, and is worthy of promotion and reference.
作者
赵淑荣
张爱华
ZHAO Shu-rong;ZAHANG Ai-hua(Department of Gastroenterology,Qixia People's Hospital,Qixia,Shandong Province,265300 China)
出处
《系统医学》
2019年第15期69-71,共3页
Systems Medicine
