摘要
目的 了解寡克隆区带电泳在格林巴利综合征(GBS)患者中的分布特点及诊断意义。方法 对首都医科大学附属北京天坛医院2013-2019年确诊为GBS的98例患者的寡克隆区带电泳结果从性别、年龄、急慢性等方面进行分析。结果 98例GBS中,脑脊液及血清中寡克隆区带阳性率接近,分别为37.8%、 33.7 %,而脑脊液中特异性寡克隆区带的阳性率为7.1%,较前者显著降低( P <0.05);不同年龄段脑脊液及血清寡克隆区带阳性率趋势基本一致,随着年龄的增长呈上升趋势,其中>50岁年龄组脑脊液及血清寡克隆区带的阳性率(52.4%、50.0%)明显高于≤50岁年龄组(26.8%、21.4%),差异有统计学意义( P <0.05)。结论 GBS患者>50岁年龄组脑脊液及血清寡克隆区带阳性率高,而脑脊液中特异性寡克隆区带的阳性率较低,提示>50岁年龄组脑脊液寡克隆区带阳性部分是由于血清中的蛋白渗透,并不全是鞘内合成,可能与老年人的血脑屏蔽功能较年轻人较差有一定关系。
Objective To understand the distribution and diagnostic significance of oligoclonal band electrophoresis in patients with Guillain-Barre syndrome (GBS). Methods The results of oligoclonal band electrophoresis in 98 patients with GBS diagnosed in Beijing Tiantan Hospital affiliated to Capital Medical University from 2013 to 2019 were analyzed from gender,age,acute and chronic aspects. Results In 98 cases of GBS,the positive rates of oligoclonal bands in cerebrospinal fluid and serum were 37.8% and 33.7%,respectively,while the positive rates of specific oligoclonal bands in cerebrospinal fluid were 7.1%,which was significantly lower than that in the former ( P <0.05).The positive rates of oligoclonal bands in cerebrospinal fluid and serum of different age groups were basically the same,and increased with age.The positive rate of oligoclonal bands in cerebrospinal fluid and serum of the group > 50 years old (52.4% and 50.0%) was significantly higher than that of the group ≤ 50 years old (26.8% and 21.4%),and the difference was statistically significant ( P <0.05). Conclusion The positive rate of oligoclonal bands in cerebrospinal fluid and serum of GBS patients > 50 years old was higher,but the positive rate of specific oligoclonal bands in cerebrospinal fluid was lower,suggesting that the positive part of oligoclonal bands in cerebrospinal fluid of GBS patients > 50 years old was due to protein penetration in serum,not all intrathecal synthesis,which may be related to the poor blood-brain shielding function of the elderly.
作者
王利娟
刘杰
陈柯霖
李斯文
谷愉愉
刘淑静
周金
康熙雄
张国军
WANG Lijuan;LIU Jie;CHEN Kelin;LI Siwen;GU Yuyu;LIU Shujing;ZHOU Jin;KANG Xixiong;ZHANG Guojun(Department of Clinical Laboratory,Beijing Tiantan Hospital Affiliated to CapitalMedical University,Beijing 100070,China;Beijing Engineering Research Center of ImmunologicalReagents Clinical Research,Beijing 100070,China)
出处
《国际检验医学杂志》
CAS
2019年第17期2085-2087,2091,共4页
International Journal of Laboratory Medicine
基金
北京市自然科学基金项目(7194261)
关键词
格林巴利综合征
寡克隆区带电泳
鞘内合成
Guillain-Barre syndrome
oligoclonal band electrophoresis
intrathecal synthesis
