摘要
骨关节炎(OA)是一种以软骨变性为主的退行性疾病,严重影响中老年患者的生活质量,并给社会带来巨大的经济损失。间充质干细胞(MSC)作为成体干细胞,成为目前OA治疗领域的研究热点之一。近年来随着细胞和组织工程技术的发展,不同来源的MSC,如骨髓MSC、脂肪MSC、滑膜MSC等被应用于关节软骨修复。关节腔内注射MSC可以显著改善OA患者的疼痛及运动功能,并可修复关节软骨缺损。MSC治疗虽然取得了较好的治疗效果,但仍存在不足之处,需要更多的临床研究及真实世界研究进行评估和优化。
Osteoarthritis(OA) is a degenerative joint disease characterized by cartilage degeneration, which tremendously affects life quality of the elderly population, and significantly increases the economic cost of public health and welfare. As a member of adult stem cells, mesenchymal stem cells(MSCs) exhibit specific feature. Over the past few decades, MSCs have become a major focus of interest in the treatment of OA. With the development of cell and tissue engineering, MSCs originating from different tissues such as bone marrow, adipose tissue and synovial tissue has been applied in the repairment of cartilage and joints. Intra-articular injection of MSCs has shown to facilitate the repair of articular cartilage, which significantly alleviates pain and improves joint movement of OA patients. While MSCs in treatment of OA has shown promising results, additional clinical trials and real-world studies are required for further evaluation and optimization of this strategy.
作者
柯旖旎
林进
KE Yi-ni;LIN Jin(Department of Rheumatology, the First Affiliated Hospital Medical College, Zhejiang University, Hangzhou 310003, China)
出处
《中国实用内科杂志》
CAS
CSCD
北大核心
2019年第8期677-680,共4页
Chinese Journal of Practical Internal Medicine
关键词
骨关节炎
间充质干细胞
osteoarthritis
mesenchymal stem cells
