摘要
目的分析艾滋病(AIDS)合并新型隐球菌脑膜炎死亡患者的临床特点,为优化临床治疗方案提供参考依据。方法回顾性分析46例AIDS合并新型隐球菌脑膜炎死亡患者的临床资料。结果239例AIDS合并新型隐球菌脑膜炎患者中,46例死亡,病死率为19.2%(46/239);46例死亡患者的临床表现无特异性,常有头痛(82.6%)、发热(47.8%)表现;脑脊液常规检查见脑脊液压力升高,71.7%患者蛋白含量正常,39.1%患者葡萄糖降低,52.2%患者氯化物降低;脑脊液涂片或培养可找到隐球菌;CD4^+T细胞计数均<150个/μL;头颅影像学检查无特征性表现。结论AIDS合并新型隐球菌脑膜炎病死率高,患者临床表现和实验室检查均不具特异性,确诊依赖病原学检查。
Objective To analyze the clinical features of death cases of AIDS complicated with Cryptococcus neoformans meningitis to provide the reference for optimizing clinical therapeutic regimen. Methods The clinical data of 46 death cases of AIDS complicated with Cryptococcus neoformans meningitis were analyzed retrospectively. Results Forty-six cases died among 239 cases of AIDS complicated with Cryptococcus neoformans meningitis,with a mortality of 19.2%(46/239);no specificity was found in the clinical manifestations of the 46 dead cases,the common manifestations were headache(82.6%) and fever(47.8%);conventional cerebrospinal fluid testing revealed increased cerebrospinal fluid pressure,normal protein content observed in 71.7% of the patients,decreased glucose in 39.1% of the patients,and decreased chloride in 52.2% of the patients;Cryptococcus was found in cerebrospinal fluid smear/culture;CD4^+T cell counts were all less than 150/μL;no typical signs were observed on brain imaging examination. Conclusion AIDS complicated with Cryptococcus neoformans meningitis has a high mortality, without a specificity for patients′ clinical manifestations or laboratory examination results,its definite diagnosis relies on etiological examination.
作者
卢焕
吴锋耀
LU Huan;WU Feng-yao(Department of Infectious Diseases,the Fourth People′s Hospital of Nanning,Nanning 530023,China)
出处
《广西医学》
CAS
2019年第14期1795-1797,1816,共4页
Guangxi Medical Journal
关键词
艾滋病
隐球菌脑膜炎
新型
死亡
临床特点
诊断
Acquired immunodeficiency syndrome
Cryptococcal meningitis
Neoformans
Death
Clinical feature
Diagnosis
