摘要
目的探讨肝硬化合并感染性休克患者的预后影响因素.方法以2013年3月至2018年2月内蒙古自治区人民医院感染科收治的96例失代偿期肝硬化合并感染性休克患者为研究对象,根据患者预后分为存活组(58例)和病死组(38例).比较两组患者性别、年龄、感染部位、基础疾病、住院时间、并发症及生物化学指标的差异,采用多因素Logistic回归分析失代偿期肝硬化合并感染性休克患者预后的影响因素.结果存活组和病死组患者肺部感染、住院时间、上消化道出血,ALB、Cr、CRP和PCT水平差异有统计学意义(P<0.05).Logistic多因素回归分析表明,肺部感染、上消化道出血、Cr≥170μmol/L、CRP≥35.0 mg/L及PCT≥2μg/L是失代偿期肝硬化合并感染性休克患者预后的独立危险因素.结论失代偿期肝硬化合并感染性休克患者的病死率高,肺部感染、上消化道出血、Cr≥170μmol/L、CRP≥35.0 mg/L和PCT≥2μg/L是其预后的独立危险因素.
Objective To investigate the prognostic risk factors for liver cirrhosis patients complicated with septic shock. Methods Total of 96 decompensated cirrhosis patients complicated with septic shock in Department of Infectious Diseases, Inner Mongolia Autonomous Region People’s Hospital from March 2013 to February 2018 were selected and divided into survival group (58 cases) and death group (38 cases) according to the prognosis. The sex, age, infection site, underlying diseases, hospital stay, complications, and biochemical indexes of patients in two groups were compared. Prognostic factors for patients with decompensated cirrhosis complicated with septic shock were analyzed by multivariate Logistic regression. Results There were significant differences in pulmonary infection, hospital stay, upper gastrointestinal bleeding, ALB, Cr, CRP and PCT of patients in two groups (P < 0.05). Multivariate Logistic regression analysis showed that pulmonary infection, upper gastrointestinal bleeding, Cr ≥ 170 μmol/L, CRP ≥ 35.0 mg/L and PCT ≥ 2 μg/L were independent risk factors for prognosis of decompensated cirrhosis with septic shock. Conclusions The mortality of decompensated cirrhosis patients with septic shock was high. Pulmonary infection, upper gastrointestinal bleeding, Cr ≥ 170 μmol/L, CRP ≥ 35.0 mg/L and PCT ≥ 2 μg/L were independent risk factors for prognosis of decompensated cirrhosis with septic shock.
作者
张亚丽
唐中权
郭换珍
ZHANG Ya-li;TANG Zhong-quan;GUO Huan-zhen(Department of Infectious Diseases, Inner Mongolia Autonomous Region People’s Hospital, Hohhot 010010, China;Department of Hepatology, The Second Hospital of Hohhot, Hohhot 010031, China)
出处
《中国肝脏病杂志（电子版）》
CAS
2019年第2期66-70,共5页
Chinese Journal of Liver Diseases：Electronic Version
关键词
肝硬化
失代偿期
感染性休克
预后
影响因素
Liver cirrhosis, compensation
Septic shock
Prognosis
Risk factors
