摘要
血友病性关节炎(haemophilic arthropathy,HA)是由自发性关节内出血及反复关节内血肿引起,以慢性疼痛、关节损伤、生活质量下降为主要临床表现的一种衰竭性疾病,晚期以关节的纤维化变性和功能丧失为特征,受累关节多为膝、肘、踝,HA典型的病理表现为滑膜炎、关节软骨破坏及软骨下骨破坏。在血友病患者中预防性应用VIII因子或者XI因子虽可以减少关节出血的发生率,但患者仍会出现突发性关节出血,有研究表明,90%以上的预防性患者在40岁前至少有一个关节出现慢性关节改变。
To review the research progress on haemophilic arthropathy( HA). Relevant literature on the pathogenesis of HA in recent years was extensively reviewed and comprehensively analyzed. Iron, cytokines/growth factors and other factors played a vital part in the pathogenesis of HA, which cooperated and interacted with each other to determine the occurrence and development. Molecular mechanisms resulting in joint deterioration are incompletely understood, although the contributions of iron deposition, inflammatory cell and cytokine/growth factor production have been individually demonstrated. It’s necessary to conduct more researches to find out the pathogenesis in detail.
作者
郑刘杰
ZHENG Liu-jie(Department of Orthopedics, the second affiliated Hospital of Anhui Medical University, Hefei, Anhui, 230601, China)
出处
《中国骨与关节杂志》
CAS
2019年第7期520-524,共5页
Chinese Journal of Bone and Joint
关键词
血友病
骨关节炎
发病机制
综述
Hemophilia
Arthrosteitis
Pathogenesis
Review
