摘要
目的探讨法舒地尔联合脑苷肌肽治疗2型糖尿病并耳鸣耳聋的临床疗效。方法选取2016年1-12月大同市第五人民医院收治的2型糖尿病并耳鸣耳聋患者60例为研究对象,采用随机数字表法分为对照组(30例)和观察组(30例),对照组给予脑苷肌肽治疗,观察组在对照组的基础上加用盐酸法舒地尔治疗,比较两组治疗10 d及20 d的有效率。结果观察组治疗10 d听力水平改善的总有效率与对照组比较[26.7%(8/30)比16.7%(5/30)],差异无统计学意义(χ^2=0.884,P=0.347),而治疗20 d的总有效率高于对照组,差异有统计学意义(χ^2=4.444,P=0.035)。观察组治疗10 d耳鸣缓解总有效率与对照组比较,差异无统计学意义(χ^2=1.491,P=0.222),而治疗20 d的总有效率高于对照组[56.7%(17/30)比30.0%(9/30)],差异有统计学意义(χ^2=4.344,P=0.037)。两组治疗前及治疗10 d时听力阈值比较,差异均无统计学意义(均P>0.05),治疗20 d观察组明显优于对照组(t=-2.511,P=0.02)。结论法舒地尔联合脑苷肌肽治疗2型糖尿病并耳鸣耳聋效果明显,疗效肯定。
Objective To study the clinical effect of fasudil plus cattle encephalon glycoside and ignotin injection in treating diabetic deafness and tinnitus. Methods From January 2016 to December 2016, 60 patients with diabetic deafness and tinnitus in the Fifth People's Hospital of Datong were selected and randomly divided into two groups according to the digital table, with 30 cases in each group.The treatment group received fasudil injection plus cattle encephalon glycoside and ignotin injection (iv gtt), and the control group received cattle encephalon glycoside and ignotin injection.The effective rate after treatment for 10 days and 20 days were compared between the two groups. Results Compared with the control group, the effective rate of hearing in the treatment group was not higher at 10 days after treatment (26.7% vs.16.7%,χ^2=0.884, P=0.347), while it was higher in the treatment group at 20 days after treatment (53.3% vs.26.7%,χ^2=4.444, P=0.035). The effective rate of tinnitus in the treatment group at 10 days after treatment was not higher compared with the control group (30.0% vs.20.0%,χ^2=1.491, P=0.222), while it was higher in the treatment group at 20 days after treatment (56.7% vs.30.0%,χ^2=4.344, P=0.037). As far as hearing threshold: there were no statistically significant differences between the control group and the observation group before treatment and 10 days after treatment(all P>0.05). The hearing threshold of the observation group was significantly better than that of the control group at 20 days after treatment (t=-2.511, P=0.02). Conclusion The combination therapy of fasudil injection plus cattle encephalon glycoside and ignotin injection has better efficacy for diabetic deafness and tinnitus.
作者
王慧卿
王桂英
李银玉
张继敏
郭平
张晋华
尉杰忠
Wang Huiqing;Wang Guiying;Li Yinyu;Zhang Jimin;Guo Ping;Zhang Jinhua;Wei Jiezhong(Department of Endocrinology, the Fifth People's Hospital of Datong, Datong, Shanxi 037004, China;Institute of Brain Science, Shanxi Datong University, Datong, Shanxi 037004, China)
出处
《中国基层医药》
CAS
2019年第15期1798-1801,共4页
Chinese Journal of Primary Medicine and Pharmacy
基金
山西省科技厅重点研发计划基金资助项目(2106ZD0505).
关键词
糖尿病
2型
耳鸣
聋
听力
法舒地尔
脑苷肌肽
疗效比较研究
Diabetes mellitus, type 2
Tinnitus
Deafness
Hearing
Fasudil
Cerebral glycoside
Comparative effectiveness research
