通心络联合丁苯酞治疗脑小血管病所致认知功能障碍的临床效果被引量：7

Clinical effect of Tongxinluo combined with butylphthalide in the treatment of cognitive dysfunction caused by cerebral small vessel disease

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摘要 :目的观察中医络病理论指导下的通心络联合丁苯酞治疗脑小血管病(CSVD)所致认知功能障碍的临床效果。方法纳入88例存在认知功能障碍的CSVD患者为研究对象,按照随机数字表法将其分为试验组(42例)和对照组(46例)。在内科常规治疗的基础上,对照组给予丁苯酞,试验组给予丁苯酞+通心络。比较两组患者的治疗效果。结果治疗后,两组MoCA评分均提高,且试验组高于对照组,差异有统计学意义(P<0.05);治疗后,两组ADL评分均提高,且试验组高于对照组,差异有统计学意义(P<0.05);试验组治疗总有效率为76.19%,显著高于对照组的52.17%(P<0.05)。结论通心络联合丁苯酞治疗CSVD所致认知功能障碍的效果优于单用丁苯酞,可显著改善患者的日常生活能力,提示中医络病理论在改善CSAD所致认知功能障碍方面具有一定优势。 Objective To observe the clinical effect of Tongxinluo under the theory of collateral disorders of traditional Chinese medicine combined with butylphthalide in the treatment of cognitive dysfunction caused by cerebral small vessel disease(CSVD).Methods Eighty-eight CSVD patients with cognitive dysfunction were included as the study objects.The patients were divided into experimental group(42 cases)and control group(46 cases)according to random number table method.On the basis of routine medical treatment,the control group was given butylphthalide,and the experimental group was given butylphthalide+Tongxinluo.The therapeutic effects of the two groups were compared.Results After treatment,the MoCA scores of both groups improved,and that in the experimental group was higher than the control group,the differences were statistically significant(P<0.05).After treatment,the ADL scores of both groups improved,and that in the experimental group was higher than the control group,the differences were statistically significant(P<0.05).The total effective rate of treatment in the experimental group was 76.19%,which was significantly higher than 52.17%in the control group(P<0.05).Conclusion Tongxinluo combined with butylphthalide in the treatment of cognitive dysfunction caused by CSVD has better effect than that of butylphthalide alone,it can significantly improve the patients'daily living ability.It may suggest that theory of collateral disorders of traditional Chinese medicine has certain advantages in improvement of cognitive dysfunction caused by CSAD.

作者周辉马菁菁罗改莹余华 ZHOU Hui;MA Qing-qing;LUO Gai-ying;YU Hua(Xi'an No.5 Hospital,Xi'an 710000;Shaanxi Traditional Chinese Medicine Hospital,Xi'an 710000,China)

机构地区西安市第五医院陕西省中医医院

出处《临床医学研究与实践》 2019年第22期65-66,79,共3页 Clinical Research and Practice

关键词脑小血管病认知功能障碍丁苯酞通心络 cerebral small vessel disease cognitive dysfunction butylphthalide Tongxinluo

分类号 R749.1 [医药卫生—神经病学与精神病学]

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