摘要
Hippo信号通路在结直肠癌发生发展中具有重要作用,是调控细胞增殖和分化的重要信号通路.Hippo信号通路中多种蛋白和基因尤其是下游的YAP在结直肠癌的发生、转移、耐药、复发中发挥重要作用.YAP及相关基因可作为预测结直肠癌放化疗药物耐药性的靶向标志物.针对Hippo信号通路基因网络的靶向治疗与联合用药为治疗结直肠癌提供了新的思路.
Hippo signaling pathway plays a significant role in the development of colorectal cancer,and acts as an important regulatory pathway which regulates cell proliferation and cell differentiation.Multiple proteins and genes in Hippo signaling pathway,especially the downstream YAP protein,play important roles in the occurrence,metastasis,drug resistance and recurrence of colorectal cancer.YAP and other related genes can be used as targeted markers for predicting drug resistance to colorectal cancer.Hippo signaling pathway gene network can be used as targeted therapy or combination therapy,thus providing new ideas for the treatment of colorectal cancer.
作者
顾思佳
孙国壮
乔大伟
仲毅
孔桂美
卜平
Gu Sijia;Sun Guozhuang;Qiao Dawei;Zhong Yi;Kong Guimei;Bu Ping(Faculty of Clinical Medicine,Medical School,Yangzhou University,Yangzhou 225001,China;Faculty of Basic Medicine,Medical School,Yangzhou University,Yangzhou 225001,China;Department of Gastroenterology,Subei People's Hospital of Jiangsu Province,Yangzhou 225001,China)
出处
《国际肿瘤学杂志》
CAS
2019年第5期299-302,共4页
Journal of International Oncology
基金
国家自然科学基金(81673736)
江苏省研究生科研与实践创新计划(SJCX18_0808).
