摘要
近年来,随着分子靶向治疗和免疫治疗的突破性进展,恶性肿瘤的治疗发生了革命性变化,但其仍然是导致目前全球疾病死亡的主要原因。研究表明,肿瘤治疗电场(tumor treating fields,TTFields)对肿瘤生长具有良好的抑制作用,其由低强度(1~2 V/cm)、中频(100~200 kHz)交流电场构成,通过阻止肿瘤细胞有丝分裂纺锤体的形成和介电电泳致细胞结构紊乱和破坏来诱导分裂期细胞的凋亡,以期达到抗肿瘤治疗的目的,且效果明显、毒副作用小和潜力大。TTFields在多种肿瘤的发生发展过程中都发挥着重要作用,其为恶性肿瘤患者的治疗带来新的福音,本文就TTFields最新的研究进展进行综述。
In recent years, with the breakthrough of molecular targeted therapy and immunotherapy, the treatment of malignant tumor has undergone revolutionary changes, but it is still the main cause of global disease death. Research has shown that tumor treating fields(TTFields) has good inhibitory effect on tumor growth by low intensity(1-2 V/cm), intermediate frequency(100-200 kHz) ac electric field, which can prevent the formation of tumor cell mitotic spindle and dielectrophoresis cell structure disturbance and destruction to induce split phase of cell apoptosis, in order to achieve the purpose of anti-tumor treatment, and the effect is obvious, small side effects and potential. TTFields plays an important role in the occurrence and development of a variety of tumors, which brings new benefits to the treatment of patients with malignant tumors. This paper reviews the latest research progress of TTFields.
作者
罗详冲
刘晶晶
王胜飞
安乐
朱家宏
毛贵兵
王周清
LUO Xiang-chong;LIU Jing-jing;WANG Sheng-fei;AN Le;ZHU Jia-hong;MAO Gui-bing;WANG Zhou-qing(Department of Cardiothoracic Surgery,Qujing Second People's Hospital, Qujing 655000, Yunnan, CHINA;Department of Pharmacy, Qujing Second People's Hospital, Qujing 655000, Yunnan, CHINA)
出处
《海南医学》
CAS
2019年第14期1877-1881,共5页
Hainan Medical Journal
关键词
肿瘤治疗电场
恶性肿瘤
有丝分裂
交流电场
治疗
Tumor treating fields
Malignant tumor
Mitosis
Ac electric field
Treatment
