摘要
目的:探讨复发或转移性孤立性纤维瘤(SFT)的临床诊治策略。方法:收集复旦大学附属中山医院2012年1月至2018年10月收治的19例复发或转移性孤立性纤维瘤患者的临床及随访资料,分析局部治疗及药物治疗的疗效。结果:10例患者复发或转移后再次行手术治疗;未手术的患者中,4例采用放射治疗,2例采用介入治疗,3例广泛转移者采用药物治疗(其中1例联合介入治疗)。19例患者随访7~79个月,中位随访43个月;1年总生存率为94.7%(18/19),2年总生存率为73.7%(14/19)。结论:复发或转移性孤立性纤维瘤进展缓慢,以局部复发多见,也可出现远处转移;再次手术疗效可靠,不可切除的患者可采用局部治疗(介入或放疗)联合药物治疗。
Objective: To explore the clinical strategy for treatment for patients with recurrent or metastatic solitary fibrous tumor. Methods: The clinical data and follow-up data of 19 patients with recurrent or metastatic solitary fibrous tumor admitted to Zhongshan Hospital, Fudan University from January 2012 to October 2018 were collected, and the curative effects of local treatment and drug therapy were analyzed. Results: Ten patients underwent operation after recurrence or metastasis. Among the patients without operation, 4 patients were treated with radiotherapy, 2 patients were treated with interventional therapy, and 3 patients with extensive metastasis were treated with drug therapy (1 combined with interventional therapy). Nineteen patients were followed up for 7-79 months, with a median follow-up of 43 months. The 1-year overall survival rate was 94.7%(18/19) and the 2-year overall survival rate was 73.7%(14/19). Conclusions: The progress of recurrent or metastatic solitary fibrous tumor is slow. Local recurrence is common and distant metastasis can also occur. Re-operation has reliable curative effect. Non-resectable patients can be treated with local therapy (interventional or radiotherapy) combined with drug therapy.
作者
张秀萍
罗荣奎
纪元
李智勇
王志明
周宇红
ZHANG Xiu-ping;LUO Rong-kui;JI Yuan;LI Zhi-yong;WANG Zhi-ming;ZHOU Yu-hong(Department of Medical Oncology,Xiamen Branch,Zhongshan Hospital,Fudan University,Xiamen 361015,Fujian,China;Department of Pathology,Xiamen Branch,Zhongshan Hospital,Fudan University,Xiamen 361015,Fujian,China;Department of Medical Oncology,Zhongshan Hospital,Fudan University,Shanghai 200032,China)
出处
《中国临床医学》
2019年第3期374-377,共4页
Chinese Journal of Clinical Medicine
关键词
孤立性纤维瘤
复发
转移
治疗
solitary fibrous tumor
recurrence
metastasis
treatment
