摘要
目的观察加减八珍汤联合营养支持对老年骨骼肌减少症的临床疗效及患者生活质量的影响。方法选取2017年3月-2018年3月就诊的214例老年骨骼肌减少症患者作为研究对象,按照随机数字表法将其分为对照组和试验组,每组107例。两组均给予营养支持干预,进行适当的体育锻炼,试验组患者加服加减八珍汤,总疗程为3个月。观察两组患者中医证候积分及临床疗效,检测患者治疗前后肌肉力量、肌肉质量、肌肉功能,观察患者治疗前后患者生活质量指标如握力、步速、骨骼肌指数(ASMI)、工具性日常生活能力(IADL)和日常生活活动能力(ADL)。结果试验组患者总有效率(95.2%)高于对照组(69.6%,P<0.01)。与本组治疗前比较,两组治疗后证候积分降低(P<0.05),肌肉功能提高(P<0.05),握力、步速、IADL及ADL升高(P<0.05)。与对照组同期比较,试验组治疗后证候积分降低(P<0.01),肌肉功能提高(P<0.05),步速、ADL升高(P<0.01,P<0.05)。结论加减八珍汤联合营养支持治疗老年骨骼肌减少症可明显改善患者的肌肉力量、肌肉质量、肌肉功能,有效提升患者的生活质量。
Objective To observe the clinical effect of Modified Bazhen Decoction(MBD)combined with nutrition support on elderly sarcopenia and the quality of life of the patients. Methods Totally 214 cases of elderly sarcopenia were recruited from March 2017 to March 2018, the patients were assigned to control group and trial group according to the random digit table, 107 cases in each group.All of the patients received nutrition support and appropriate physical exercise,patients in the trial group took MBD additionally,the total treatment course was 3 months. The syndrome score and clinical effect of the two groups was observed,muscle strength,muscle mass and muscle function were measured before and after treatment,and quality of life indicators including grip strength,walking speed,appendicular skeletal muscle index(ASMI),instrumental activities of daily living(IADL)and activities of daily living(ADL) were observed before and after treatment. Results The total effective rate in the treatment group(95.2%)was higher than that in the control group(69.6%, P< 0.01). Compared with before treatment in the same group,the syndrome score were decreased(P<0.05),the muscle function, step speed, IADL and ADL in both groups were increased(P<0.05).Compared with control group,the syndrome score was decreased(P<0.01),the muscle function,grip strength,step speed, ADL in trial group were increased(P<0.01, P<0.05). Conclusion Modified Bazhen Decoction combined with nutrition support can significantly improve the patient’s muscle strength,muscle mass,muscle function,and improve the patient’s quality of life.
作者
梁清月
王仲
刘戎
刁燕青
LIANG Qingyue;WANG Zhong;LIU Rong;DIAO Yan-qing(Department of Nutrition,Chengdu Fifth People's Hospital,Chengdu 611130)
出处
《中国中西医结合杂志》
CAS
CSCD
北大核心
2019年第7期821-825,共5页
Chinese Journal of Integrated Traditional and Western Medicine
关键词
加减八珍汤
营养支持
老年骨骼肌减少症
生活质量
Modified Bazhen Decoction
nutrition support
elderly sarcopenia
quality of life
