摘要
目的探讨老年2型糖尿病患者轻度认知功能障碍与胰岛素抵抗、白介素-6的相关性。方法选择我院2017年2月~2018年5月收治的老年2型糖尿病患者200例,根据是否存在轻度认知功能障碍分为观察组和对照组,各100例,所有患者进行空腹血糖(FBG)、空腹胰岛素(FINS)、白介素-6(IL-6)、糖化血红蛋白(HbA1c)、总胆固醇(TC)、甘油三脂(TG)、低密度脂蛋白胆固醇(LDL-C)测定,计算胰岛素抵抗指数(HOMA-IR),比较两组各指标差异,Logistic回归分析老年2型糖尿病患者认知障碍的影响因素。结果观察组患者的FBG(8.72±0.36)mmol/L、FINS(11.46±3.45)μU/ml、IL-6(14.78±2.34)pg/ml、HbA1c(8.56±1.46)%、TC(6.76±1.31)mmol/L、HOMA-IR(5.15±1.62)均高于对照组的FBG(7.14±0.46)mmol/L、FINS(6.91±1.56)μU/ml、IL-6(6.92±1.54)pg/ml、HbA1c(7.91±1.75)%、TC(6.12±1.54)mmol/L、HOMA-IR(4.16±1.50),差异均有统计学意义(P<0.05);多因素Logistic回归分析显示,HOMA-IR、IL-6为老年2型糖尿病患者MCI发生的独立危险因素(P<0.05)。结论胰岛素抵抗、IL-6水平上升与老年2型糖尿病患者轻度MCI的发生存在相关性,可能是其主要危险因素,应早期干预。
Objective To investigate the relationship between mild cognitive impairment and insulin resistance and interleukin-6 in elderly patients with type 2 diabetes.Methods We selected 200 elderly patients with type 2 diabetes admitted from February 2017 to May 2018 in our hospital. According to the presence or absence of mild cognitive impairment, we divided into observation group and control group, 100 cases each, and all patients underwent fasting blood glucose (FBG), fasting insulin (FINS), interleukin-6 (IL-6), glycated hemoglobin (HbA1c), total cholesterol (TC), triglyceride (TG), low-density lipoprotein cholesterol (LDL-C) determination, calculation of insulin Resistance index (HOMA-IR), comparing the differences between the two groups, Logistic regression analysis of the influencing factors of cognitive impairment in elderly patients with type 2 diabetes.Results FBG (8.72±0.36) mmol/L, FINS (11.46±3.45)μU/ml, IL-6 (14.78±2.34) pg/ml, HbA1c (8.56±1.46)%, TC (6.76±1.31) mmol/L and HOMA-IR (5.15±1.62) in the observation group were higher than those of the control group (7.14±0.46) mmol/L, FINS (6.91±1.56)μU/ml, IL-6 (6.92±1.54) pg/ml, HbA1c (7.91±1.75)%, TC (6.12±1.54) mmol/L, HOMA-IR (4.16±1.50), the difference was statistically significant (P<0.05);multivariate logistic regression analysis HOMA-IR and IL-6 were independent risk factors for MCI in elderly patients with type 2 diabetes (P<0.05).Conclusion Insulin resistance and elevated IL-6 levels are associated with mild MCI in elderly patients with type 2 diabetes, which may be the main risk factors and should be intervened early.
作者
谢小莉
李燕
霍敏
毕立兵
翟紫翔
XIE Xiao-li;LI Yan;HUO Min;BI Li-bing;ZHAI Zi-xiang(Department of Neurology,Yinchuan Second People's Hospital,Yinchuan 750011,Ningxia,China)
出处
《医学信息》
2019年第15期97-98,108,共3页
Journal of Medical Information
基金
宁夏回族自治区卫生计生委科研项目资助的重点研究课题(编号:2016-NW-081)
