摘要
目的研究持续及慢性血小板减少症患儿Th17、Treg细胞水平表达情况。方法选择43例于某院治疗的慢性血小板减少症患儿作为实验组,另选取43例同期某院健康体检儿童作为对照组,纳入时间为2016年10月至2017年10月,分别对研究对象Th17、Treg细胞水平予以检测,对比两组儿童Th17、Treg细胞水平,比较血小板减少症患儿治疗前后Th17、Treg细胞水平。结果实验组Th17、Th17/Treg水平高于对照组,与对照组相比,实验组Treg细胞水平较低,组间差异有统计学意义(P<0.05)。经治疗慢性血小板减少症患儿Th17细胞比例、Th17/Treg有所降低,Treg细胞水平得以提升,治疗前后差异有统计学意义(P<0.05)。结论持续及慢性血小板减少症患儿Th17、Treg细胞水平与健康儿童之间具有显著差异,上述指标可作为血小板减少症诊断数据支持,同时也能够反映患儿临床治疗效果。
Objective To study the expression of Th17 and Treg cells in children with persistent and chronic thrombocytopenia.Methods 43 children with chronic thrombocytopenia treated in a hospital from October 2016 to October 2017 were selected as the experimental group while 43 children undergoing physical examination at the same time were included in the study as the control group.The levels of Th17 and Treg cells were measured and compared between the two groups.Th17 and Treg cell levels in children with chronic thrombocytopenia were compared before and after the treatment.Results The levels of Th17 and Th17/Treg in the experimental group were higher than those in the control group.Compared with the control group,the levels of Treg cells in the experimental group were lower and the differences between the two groups were statistically significant(P<0.05).Th17 cell ratio,Th17/Treg ratio decreased and Treg cell level increased in children with chronic thrombocytopenia after treatment and the difference was statistically significant before and after the treatment(P<0.05).Conclusion Th17 and Treg cell levels in children with persistent and chronic thrombocytopenia were significantly different from those of healthy children.These indexes could be used as diagnostic data for thrombocytopenia and also reflect the clinical curative effect.
出处
《中国疗养医学》
2019年第8期824-825,共2页
Chinese Journal of Convalescent Medicine
