摘要
肝纤维化是指肝在修复各种致病因子所致肝损伤时出现的肝内弥漫性细胞外基质过度沉积。近年来,越来越多证据表明第10号染色体缺失的磷酸酶张力蛋白同源物基因(phosphatase and tensin homology deleted on chromosome ten,PTEN)参与肝纤维化进程。本文就PTEN调控肝纤维化的机制研究进行综述。
Liver fibrosis is caused due to excessive deposition of diffuse extracellular matrix in the liver during repair of liver injury caused by various pathogenic factors.In recent years,an increasing body of evidence has suggested that the phosphatase and tensin homology deleted on chromosome 10(PTEN)is involved in the development of liver fibrosis.We therefore reviewed the regulatory mechanism of PTEN in liver fibrosis.
作者
陈晴晴
孙芬芬
张欣
潘伟
杨晓莹
CHEN Qingqing;SUN Fenfen;ZHANG Xin;PAN Wei;YANG Xiaoying(Jiangsu Key Laboratory of Immunity and Metabolism,Department of Pathogenic Biology and Immunology,Xuzhou Medical University,Xuzhou 221004,China;Department of Clinical Medicine,Xuzhou Medical University,Xuzhou 221004;National Experimental Teaching Demonstration Center of Basic Medicine (Xuzhou Medical University),Xuzhou 221004)
出处
《中国比较医学杂志》
CAS
北大核心
2019年第7期92-95,107,共5页
Chinese Journal of Comparative Medicine
基金
国家自然科学基金(81871670,81800718)
大学生创业创新训练计划项目(201810313063X)
徐州医科大学“挑战杯/创青春”重点培育项目(18ZK09)
江苏高校品牌专业建设工程一期项目(PPZY2015B161)
