摘要
用二环己基碳二酰亚胺(DCC)和1-乙基-(3-二甲基氨基丙基)碳二亚胺(EDC)作为脱水缩合剂,分别催化具羧基末端的硫代氨基甲酸酯与N-Boc-乙二胺反应,合成具末端Boc氨基的硫代氨基甲酸酯,用1HNMR谱证明所得产物为预期结构。并对两种方法进行了比较研究,结果表明,EDC为脱水缩合剂时,实验操作简单、反应时间短、后处理无需加入有机溶剂,产率更高。
Dicyclohexyl carbodiimide (DCC ) or 1-ethyl-(3-dimethylaminopropyl ) carbodiimide (EDC ) was used as a dehydrating condensing agent to catalyze the reaction of thiocarbamate having a terminal carboxyl group with N-Boc-ethylenediamine to synthesize thiocarbamate with a terminal tert-butyloxycarbonyl (Boc ) amine group. The structure of the product was demonstrated by 1H NMR spectra. The two methods were compared and the results showed that when EDC was a dehydrating condensing agent, the experimental operation was simple, the reaction time was short, the post-treatment did not require the addition of an organic solvent, and the yield was higher.
作者
王雨佳
游丹
危俊吾
林峰
钱杨杨
毕韵梅
WANG Yu-jia;YOU Dan;WEI Jun-wu;LIN Feng;QIAN Yang-yang;BI Yun-mei(College of Chemistry and Chemical Engineering, Yunnan Normal University, Yunnan Kunming 650500, China)
出处
《广州化工》
CAS
2019年第13期57-58,共2页
GuangZhou Chemical Industry
基金
国家自然科学基金(21564017)资助项目
