摘要
目的了解单核细胞增生李斯特菌感染的临床特点,为完善诊断及经验治疗提供理论依据。方法回顾性分析2015年1月-2017年12月宁夏医科大学总医院单核细胞增生李斯特菌感染患者的临床特点。结果共收集19例患者,女性多于男性,且主要为50岁以上中老年人和10岁以下儿童。标本来源以脑脊液和血液为主,分别占46.2%和42.3%。患者主要临床表现为发热,11例有菌血症。所有送检标本中共收集26株单核细胞增生李斯特菌,取患者第一株菌做药敏试验,19株菌对青霉素、氨苄西林、甲氧苄啶-磺胺甲唑、美罗培南100%敏感。结论单核细胞增生李斯特菌主要引起血流感染和脑膜炎等,若抗生素使用不当,感染的预后不佳。该组患者中分离的单核细胞增生李斯特菌对青霉素、氨苄西林、甲氧苄啶-磺胺甲唑、美罗培南均有较高的敏感率,提示这些药可作为治疗单核细胞增生李斯特菌感染的经验用药。
Objective To investigate the clinical characteristics of infections caused by Listeria monocytogenes for better management of such infections.Methods Nineteen cases of listeriosis were treated in the General Hospital of Ningxia Medical University during the period from January 2015 to December 2017.The specimen sources of pathogens,clinical characteristics and antibiotic resistance were analyzed retrospectively.Results A total of 26 strains of Listeria monocytogenes were isolated from 19 patients (15 females,4 males),mainly from cerebrospinal fluid (46.2%,12/26) and blood (42.3%,11/26).The major clinical symptoms were fever.Bacteremia was documented in 11 patients.19 strains of Listeria monocytogenes isolates were susceptible to ampicilin, penicilin,meropenem and trimethoprim-sulfamethoxazole.Conclusions Listeria monocytogenes isolates are still highly susceptible to ampicilin,penicilin,meropenem and trimethoprim-sulfamethoxazole,which can be used for empirical therapy of listeriosis.
作者
陶佳
杨佰虎
马红
殷国民
杨丹
顾常梅
李刚
TAO Jia;YANG Baihu;MA Hong;YIN Guomin;YANG Dan;GU Changmei;LI Gang(Center for Laboratory Medicine,General Hospital of Ningxia Medical University,Yinchuan 750004,China)
出处
《中国感染与化疗杂志》
CAS
CSCD
北大核心
2019年第4期392-395,共4页
Chinese Journal of Infection and Chemotherapy
基金
宁夏医科大学校级项目（XZ2018008）
