摘要
先天性心脏病(congenital heart disease,CHD)是最常见的儿童心血管疾病,占出生缺陷首位,严重威胁人类健康。随着医疗器械研发与技术进步,介入治疗目前已成为房间隔缺损、室间隔缺损、动脉导管未闭等部分类型CHD首选治疗方法。但目前所用封堵器均为镍钛合金封堵器,被植入人体后将永久存在。而封堵器植入人体6个月后,其表面内皮化就失去了存在价值。理想封堵器应在内皮化后可逐渐降解至消失,避免金属封堵器永久存在。随着医用材料的开发,这种理想已成为可能。
Congenital heart disease(CHD)is one of the most common cardiovascular diseases in children,which ranks the first place of birth defects and severely threatens human health.With the developments of medical apparatus and progress of medical technology,interventional therapy has already become the preferred therapeutic choice for certain types of CHD including atrial septal defect;ventricular septal defect and patent ductus arteriosus,etc.However;occluders currently used are made ofNiTi,which exist permanently in human body after implantation.Generally the surface endothelialization of occluders makes them lose its significance of existence 6 months after implantation.Ideal occluders should gradually undergo self degradation till they vanish,thus avoiding the permanent existence of metal materials.Nowadays,with the development of medical materials,such an idea has become possible.
作者
王琦光
朱鲜阳
WANG Qi-guang;ZHU Xian-yang(Department of Congenital Heart disease,General Hospital of Northern Theater Command,Shenyang 110840,China)
出处
《中国实用内科杂志》
CAS
CSCD
北大核心
2019年第7期579-582,共4页
Chinese Journal of Practical Internal Medicine
关键词
先天性心脏病
介入治疗
生物可降解
封堵器
congenital heart disease
interventional therapy
biodegradable
occluder
