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全肠内营养在克罗恩病中的应用 被引量:7

Application of Exclusive Enteral Nutrition in Crohn’s Disease
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摘要 全肠内营养(EEN)是儿童克罗恩病(CD)的首选治疗方案,缓解率达 80%。但 EEN对成人 CD的疗效差异较大,并且不同地区对 EEN作为成人 CD一线治疗方案的态度不一。EEN可通过调节免疫细胞、减轻肠道炎症、改变肠道菌群来缓解 CD。本综述旨在评估 EEN缓解儿童和成人 CD的疗效,讨论 EEN的种类、治疗时间、给予量、恢复至常规饮食方式等。EEN诱导 CD缓解的机制以及筛选对 EEN有效的 CD群体是未来研究的重点。 Exclusive enteral nutrition (EEN) is the preferred treatment for paediatric Crohn's disease (CD) and the remission rate is up to 80%. However, EEN has a significant difference in the efficacy of adult CD, and different regions have different attitudes toward EEN as first-line treatment of adult CD. EEN can induce the remission of CD by regulating cellular immune function, altering intestinal inflammation and altering microbiome. In this review, we evaluate the efficacy of EEN in achieving remission of CD in children and adults and discuss the types of enteral nutritions, the duration of treatment, the volume of EEN and food reintroduction. The mechanism of EEN inducing CD remission and the screening the CD populations who are response to EEN are the focus of future research.
作者 李伟杰 吴秀文 郑涛 任建安 LI Wei-jie;WU Xiu-wen;ZHENG Tao reviewing;REN Jian-an checking(Jinling Hosp Research Institute of General Surgery,Department of General Surgery, General Hosp of Eastern Theater Command, Nanjing 210002, Jiangsu, China)
出处 《肠外与肠内营养》 CSCD 北大核心 2019年第3期184-188,共5页 Parenteral & Enteral Nutrition
基金 江苏省社会发展重点项目(BE2016752)
关键词 克罗恩病 营养 全肠内营养 Crohn's disease Nutrition Exclusive enteral nutrition
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