摘要
目的系统评价心理干预联合药物治疗抑郁症的疗效和不良反应,为抑郁症的治疗提供依据。方法检索2000年1月~2018年7月PubMed、Medline、清华同方(CNKI)、万方、维普等全文数据库中公开发表的有关心理干预联合药物治疗抑郁症疗效的论文,使用Review Manager5.3软件对纳入研究的文献进行Meta分析。结果经过文章质量的评价,共纳入19篇文献,1 598名患者,其中研究组808例,治疗有效例数741例;对照组790例,治疗有效例数585例。Meta分析表明心理干预联合药物治疗与单纯的药物治疗相比差异有统计学意义(OR=4.06,95%CI:3.00~5.50,P<0.00001)。根据干预药物的种类进行亚组分析,结果显示亚组间无异质性(I2=0%)。心理干预联合药物治疗与单纯的药物治疗在不良反应方面无统计学差异(OR=0.65,95%CI:0.37~1.16,P=0.15)。结论心理干预联合药物治疗抑郁症比单纯的药物治疗更有效。
Objective To systematically evaluate the efficacy and adverse reactions of psychological intervention combined with drugs in the treatment of depression,so as to provide a basis for the treatment of depression.Methods To retrieve the published papers on the efficacy of drug combined with psychological intervention in the treatment of depression published in the full-text database of PubMed,Tsinghua Tongfang(CNKI),Wanfang and VIP from 2005 to 2018.The Review Manager software was used for Meta analysis of the included literature.Results After the evaluation of the quality of the article,19 articles and 1598 patients were included,(808 in the study group,741 in the effective treatment,790 in the control group,and 585 in the effective treatment).Meta-analysis showed that the difference between psychological intervention and drug therapy was statistically significant(OR=4.06,95%CI:3.00~5.50,P<0.01).Subgroup analysis based on the type of intervention drug showed no heterogeneity between the subgroups(I^2=0%).There was no significant difference in adverse reactions between psychological intervention and simple drug therapy(OR=0.65,95%CI:0.37~1.16,P=0.15). Conclusion Psychological intervention combined with drug therapy for depression is more effective than simple drug therapy.
作者
王莹
韩立欣
杭荣华
Wang Ying;Han Lixin;Hang Ronghua(Department of Culture and Management,Wannan Medical College,Wuhu,Anhui 241002,China)
出处
《湘南学院学报（医学版）》
2019年第2期10-14,共5页
Journal of Xiangnan University（Medical Sciences）
基金
2017年安徽省高校人文社科重点研究基地项目(SK2017A0209)
关键词
心理干预
药物治疗
抑郁症
META分析
psychological intervention
drug treatment
depression
Meta-analysis
