摘要
目的探讨自拟活血消癥汤联合米非司酮对子宫肌瘤剔除术后气虚血瘀证患者激素水平及卵巢功能的影响。方法将符合入选标准的 90 例行子宫肌瘤剔除术的患者,采用随机数字表法分为 2组,每组 45 例。对照组口服米非司酮,观察组对照组基础上加服自拟活血消癥汤。 2 组均连续治疗 3 个月,随访 2 年。采用 ELISA 法检测转化生长因子-β3(Transforming growth factor-β3, TGF-β3)、IL-22 及 FSH、促黄体生成素(luteinizing hormone, LH)、 E2、孕酮、睾酮水平,采用彩色多普勒超声仪进行子宫形态检查,比较治疗前后子宫体积变化,记录随访期间子宫肌瘤复发率。结果治疗后,观察组血清FSH[(17.11±4.01)?g/L 比(20.16±5.21)?g/L, t=3.112]、 LH[(16.78±3.34)?g/L 比(19.52±4.32)?g/L,t=3.366]、 E2[(156.60±46.32)pmol/L 比(220.31±50.11)pmol/L, t=6.263]、孕酮[(8.37±2.50)?g/L 比(15.23±2.45)?g/L, t=13.1467]、睾酮[(0.23±0.05)ng/ml 比(0.31±0.06)ng/ml, t=6.8712]、 TGF-β3[(22.08±4.34)?g/L 比(28.10±5.02)?g/L, t=6.086]水平均低于对照组(P<0.01);治疗后,观察组子宫体积[(85.42±19.35)cm3 比(97.37±20.45)cm3, t=2.847]小于对照组(P<0.01)。随访 2 年,观察组子宫肌瘤总复发率为 13.3%(6/45)、对照组为 31.1%(14/45),2 组比较差异有统计学意义(χ2=4.114,P=0.043)。结论自拟活血消癥汤联合米非司酮可有效缩小子宫体积,降低复发率、抑制卵巢激素分泌功能,降低TGF-β3 及性激素水平。
Objective To investigate the effect of Huoxue-Xiaozheng decoction on ovarian function and mifepristone of in patients with uterine leiomyoma after operation. Methods A total of 90 patients with uterine leiomyoma after operation were divided into the observation group and control group according to random number table method, with 45 cases in each group. The control group were treated with mifepristone, and the observation group with Huoxue-Xiaozheng decoction on the basis of the control group. The serum sex hormone (FSH, LH, E2, P and T), cell factor (TGF-β3, IL-22, FSH, LH, E2, P and T) and the uterine volume between two groups after treatment were compared, and the recurrence rate of uterine leiomyoma was compared between the two groups after treatment. Results After treatment, the serum sex hormone FSH (17.11 ± 4.01 ?g/L vs. 20.16 ± 5.21 ?g/L, t=3.112), LH (16.78 ± 3.34 ?g/L vs. 19.52 ± 4.32 ?g/L, t=3.366), E2 (156.60 ± 46.32 pmol/L vs. 220.31 ± 50.11 pmol/L, t=6.263), P (8.37 ± 2.50 ?g/L vs. 15.23 ± 2.45 ?g/L, t=13.1467), T (0.23 ± 0.05 ng/ml vs. 0.31± 0.06 ng/ml, t=6.8712), cell factor TGF-β3 (22.08 ± 4.34 ?g/L vs. 28.10 ± 5.02 ?g/L, t=6.086) of the observation group were significantly lower than those of the control group (P<0.01). After treatment, the uterine volume (85.42 ± 19.35 cm3 vs. 97.37 ± 20.45 cm3, t=2.847) of the observation group was significantly lower than that of the control group (P<0.01). After 2 years of follow-up, the uterine fibroids overall recurrence rate of the observation group was 13.3%(6/45), while the control group was 31.1%(14/45),. The difference between two groups, was statistically significant (χ2=4.114, P=0.043). Conclusions The Huoxue-Xiaozheng decoction combined with mifepristone can effectively inhibit the secretion of ovarian hormones and decrease the expression of TGF-β3, IL-22 , FSH, LH, E2, P and T in patients with uterine leiomyoma.
作者
齐振荣
韩超
Qi zhenrong;Han Chao(The People's Hospital of Hengshui, Hengshui 053000, China;Reproductive Medicine of Department, the People's Hospital of Hengshui, Hengshui 053000, China)
出处
《国际中医中药杂志》
2019年第6期569-572,共4页
International Journal of Traditional Chinese Medicine
关键词
子宫肌瘤切除术
卵巢功能
活血消癥汤
米非司酮
复发
子宫体积
Uterine myomectomy
Ovarian function
Huoxue-Xiaozheng decoction
Mifepristone
Recurrence
Uterine volume
