摘要
目的:探究胰岛素泵联合前列地尔治疗老年糖尿病患者周围神经病变的临床疗效。方法:选择我院收治的134例老年糖尿病周围神经病变患者,随机分为常规治疗组和联合治疗组(在常规治疗基础上采用胰岛素泵与前列地尔联合治疗),各67例。治疗2周后,对比两组患者临床疗效,治疗前后血脂、血清超氧化物歧化酶(SOD)、谷胱甘肽过氧化物酶(GSH-Px)等水平变化。结果:治疗后,联合治疗组治疗总有效率显著高于常规治疗组(92.5%比74.6%,P=0.005);与常规治疗组比较,治疗后联合治疗组血清SOD[(78.54±9.48)nU/ml比(88.29±9.08)nU/ml]、GSH-Px[(486.53±32.84)U/L比(552.31±89.86)U/L]、高密度脂蛋白-胆固醇[HDL-C,(5.88±1.48)mmol/L比(6.59±1.63)mmol/L]水平显著升高,治疗后血清甘油三酯[TG,(2.05±0.34)mmol/L比(1.35±0.26)mmol/L]、低密度脂蛋白-胆固醇[LDL-C,(3.48±0.48)mmol/L比(2.48±0.88)mmol/L]水平显著降低(P均=0.001)。结论:胰岛素泵联合前列地尔治疗老年糖尿病周围神经病变效果显著,能显著改善患者血脂水平,缓解氧化应激状态,值得推广。
Objective:To explore therapeutic effect of insulin pump combined alprostadil on diabetic peripheral neuropathy (DPN) in aged patients. Methods:A total of 134 aged DPN patients treated in our hospital were selected and randomly,equally divided into routine treatment group and combined treatment group (received insulin pump combined alprostadil based on routine treatment), both groups were treated for two weeks. Therapeutic effect, levels of blood lipids, serum superoxide dismutase (SOD) and glutathione peroxidase (GSH-Px) before and after treatment were compared between two groups. Results:After treatment, total effective rate of combined treatment group was significantly higher than that of routine treatment group (92.5%比74.6%, P =0.005). Compared with routine treatment group after treatment, there were significant rise in serum levels of SOD[(78.54±9.48) nU/ml vs.(88.29±9.08) nU/ml], GSH-Px[(486.53±32.84) U/L vs.(552.31±89.86) U/L]and high density lipoprotein cholesterol [HDL-C,(5.88±1.48) mmol/L vs.(6.59±1.63) mmol/L], and significant reductions in serum levels of triglyceride [TG,(2.05±0.34) mmol/L vs.(1.35±0.26) mmol/L]and low density lipoprotein cholesterol [LDL-C,(3.48±0.48) mmol/L vs.(2.48±0.88) mmol/L]in combined treatment group, P =0.001 all. Conclusion:Insulin pump combined alprostadil possess significant therapeutic effect on aged DPN patients. It can significantly improve blood lipid levels, and relieve oxidative stress state, which is worth extending.
作者
高妍
李立彬
曹梅娜
林荣
赵婷丽
张文
GAO yan;LI Li-bin;CAO Mei-na;LIN Rong;ZHAO Ting-li;ZHANG Wen(Third Department of Internal Medicine, General Hospital of Jizhong Energy Xingtai Mining Group Co., Ltd, Xingtai, Hebei, 054000, China)
出处
《心血管康复医学杂志》
CAS
2019年第3期348-352,共5页
Chinese Journal of Cardiovascular Rehabilitation Medicine
