摘要
克隆特异AT序列结合蛋白(SATB1)是一种组织特异性核基质结合蛋白,主要在胸腺细胞中高表达,在胸腺的生长发育及T细胞的生长和分化进程中发挥重要作用,是调节免疫系统的一个关键因素,能调控T细胞分化过程中多种基因的表达进而影响T细胞的活化,参与染色质重塑机制,调节多种基因的表达。且SATB1在多种恶性肿瘤中异常表达,在消化系统癌症如食管癌、胃癌、肝癌、胰腺癌及结直肠癌中高表达,并影响着这些肿瘤的发生、发展及预后。
Special AT-rich binding protein-1(SATB1) is a tissue-specific nuclear matrix-binding protein. It is highly expressed in thymocytes and plays an important role in the growth and development of thymus and the growth and differentiation of T cells. SATB1 is a key factor in regulating the immune system. It can regulate the expression of many genes in the process of T cell differentiation, then affect the activation of T cells, participate in the mechanism of chromatin remodeling, and regulate the expression of many genes. Moreover, SATB1 is abnormally expressed in many malignant tumors, and is highly expressed in digestive system cancers such as esophageal, gastric, liver, pancreatic and colorectal cancers, which affects the occurrence, development and prognosis of these tumors.
作者
龚丹
陈涛
刘繁荣
曹金玉
徐向群
GONG Dan;CHEN Tao;LIU Fan- rong(Department of Pathology, Second Affiliated Hospital of Nanchang University, Nanchang 330006 , China)
出处
《中国实用医药》
2019年第15期188-190,共3页
China Practical Medicine
基金
江西省卫计委科技计划(项目编号:20143100)
