摘要
目的分析内皮细胞微粒(EMPs)水平与急性冠状动脉综合征(ACS)患者冠状动脉狭窄程度的相关性。方法纳入在笔者医院心内科住院并行冠状动脉造影术的患者120例作为研究对象,分为ACS组90例,非冠心病组30例,根据冠状动脉造影结果,ACS组分为单支病变组13例,双支病变组14例,3支病变组30例,多支病变组33例。每个研究对象在冠状动脉造影前晨起空腹抽取外周静脉血,分析血脂、血糖、生化指标等,并采用流式细胞术检测血浆EMPs水平,并依据冠状动脉造影结果计算Gensini积分,比较单支病变组、双支病变组、3支病变组及多支病变组间EMPs水平与Gensini积分的关系。结果非冠心病组与ACS组比较,ACS组EMPs水平、年龄、性别、糖尿病、吸烟、超敏C反应蛋白、LVEF等均明显高于对照组,差异有统计学意义(P<0.05)。EMPs水平与Gensini积分呈正相关,单支病变组、双支病变组、3支病变组及多支病变组采用方差分析并进行组间比较,显示多支病变组EMPs水平明显高于单支病变组及双支病变组,其中单支病变组内皮细胞微粒水平最低。结论ACS组患者的血浆EMPs水平显著高于非冠心病组,EMPs水平与冠状动脉病变严重程度密切相关,EMPs水平对冠状动脉病变严重程度具有较可靠的预测价值。
Objective To analyze the correlation between the level of endothelial microparticles (EMPs) and the degree of coronary artery stenosis in patients with acute coronary syndrome (ACS).Methods Totally 120 patients who underwent concurrent coronary angiography in our department of cardiology were enrolled.A total of 120 patients undergoing coronary angiography in our hospital were divided into ACS group ( n =90) and noncoronary heart disease group ( n =30).According to the results of coronary angiography,ACS group consisted of 13 patients with single vessel disease,14 patients with double vessel disease,30 patients with three vessel disease and 33 patients with multi-vessel disease.The parapheral blood was drawed from each subject in the morning before coronary angiography to analyze blood lipids,blood glucose and biochemical indicators.Etc,and the level of plasma EMPs was detected by flow cytometry.The Gensini score was calculated according to the results of coronary angiography.The EMPs level and Gensini score were compared between single-vessel disease group,double-vessel disease group,three-vessel disease group and multi-vessel disease group.Results Compared with the ACS group,the levels of EMPs,age,gender,diabetes,smoking,hypersensitive C-reactive protein,and LVEF in the ACS group were significantly higher than those in the control group ( P <0.05).The level of EMPs was positively correlated with Gensini score.The single-vessel disease group,double-vessel disease group,three-vessel disease group and multi-vessel disease group were analyzed by variance analysis and compared between each groups.The results showed that the level of EMPs in multi-vessel lesion group was significantly higher than that in single-vessel group and double-vessel group,among which the single-vessel group had the lowest level of endothelial particles.Conclusion The plasma EMPs level in patients with ACS is significantly higher than that in non-coronary heart disease.The level of EMPs is closely related to the severity of coronary artery disease.The level of EMPs has a reliable predictive value for the severity of coronary lesions.
作者
帕提古丽·喀迪尔江
穆叶赛·尼加提
Patiguli·Kadierjiang;Muyesai·Nijiati(Xinjiang Medical University Graduate School,Xinjiang 830000, China)
出处
《医学研究杂志》
2019年第5期38-41,45,共5页
Journal of Medical Research
基金
国家自然科学基金资助项目(81760068)
新疆医科大学研究生创新创业项目(XJGRI2017091,CXCY2017039)
