摘要
目的:探讨磁共振定量非对称回波的最小二乘估算法迭代水脂分离序列(IDEAL-IQ)技术在急性胰腺炎诊断及治疗中的应用价值。方法:搜集2016年10月-2018年12月急性胰腺炎患者及正常对照组各40例,其中急性胰腺炎治疗前为A组,有效治疗1周后为B组,正常对照组为C组;分别行MRIT1WI、T2WI、IDEAL-IQ成像,分别在脂肪分数图和R2*弛豫率图对胰腺头、体、尾部兴趣区脂肪分数值(FF)和R2*值,比较各组对象FF、R2*值差异;分析急性胰腺炎治疗前后FF、R2*差值与血清胰淀粉酶(P-Amy)、脂肪酶(Lps)浓度差之间的相关性。结果:A组(9.84±1.62)、B组(6.51±1.49)、C组(4.93±1.16)FF值(%)差异有统计学意义(P<0.001);A组(26.26±4.86)、B组(19.05±6.65)、C组(13.47±6.43)R2*值(Hz)差异有统计学意义(P<0.001)。相关分析显示△FFA-B、△R2*A-B与△P-AmyA-B和△LpsA-B均呈中度正相关(P<0.001)。结论:IDEAL-IQ是一种可重复性好、结果可靠的非侵入性胰腺脂肪定量方法,可对急性胰腺炎患者胰腺内的脂肪含量、铁含量进行定量分析,对急性胰腺炎的诊断及治疗具有重要的指导价值。
Objective: To investigate the value of IDEAL-IQ sequence in quantitative assessment of steatosis and iron deposition in pancreas with acute pancreatitis (AP). Methods: 40 AP patients and 40 healthy control subjects were performed a MR scan with both IDEAL-IQ sequence and routing T 1W,T 2W.Fat fraction (FF) and R2* values were obtained for each part of the pancreas of each group by measuring on fat and R2* maps.The differences of FF and R2 * values among control group,pre-treatment and post-treatment (1 week) of AP group were compared;and the correlation between the mean differences of FF (△FFA-B ),R2* values (△R2* A-B ) and the mean differences of pancreatic amylase (△P-AmyA-B ) and lipase (△LpsA-B ) before and after treatment were analyzed respectively. Results: There were significant differences in FF (control 4.93±1.16,Pre-treatment 9.84±1.62,Post-treatment 6.51±1.49) and R2* value (control 13.47±6.43,Significant statistic differences were found among three groups (all P <0.05).And the mean values were as follows:FF (%) values of group A (9.84±1.62),group B (6.51±1.49),and group C (4.93±1.16),R2*(Hz) values of group A (26.26±4.86),group B (19.05±6.65),and group C (13.47±6.43).△FFA-B and △R2*A-B were positively correlated with △P-AmyA-B and △LpsA-B ,respectively (all P <0.001). Conclusion:Pancreas may have fat and iron deposition in AP.IDEAL-IQ sequence can be used to quantitatively assess steatosis and iron overload in pancreas parenchyma.△FFA-B and △R2*A-B may have potential values to predict the efficacy of AP treatment.
作者
张志诚
江才明
陈维
黄杰
郑波
ZHANG Zhi-cheng;JIANG Cai-ming;CHEN Wei(Department of Radiology,the Ninth People's Hospital of Chongqing 400700,China)
出处
《放射学实践》
北大核心
2019年第6期686-690,共5页
Radiologic Practice
关键词
急性胰腺炎
脂肪分数
磁共振成像
脂肪酶
Acute pancreatitis
Fat fraction
Magnetic resonance imaging
Lipase
