摘要
目的:探讨自乳化释药系统(SEDDS)对丹参酮类组分增溶的效果。方法:采用D-最优混料设计优化SEDDS处方,以隐丹参酮、丹参酮Ⅰ和丹参酮Ⅱ_A含量、SEDDS的粒径和乳化时间为指标对SEDDS进行优化并对其进行综合评价。结果:优化得SEDDS最佳处方为:油酸∶吐温-20∶二乙二醇单乙基醚(0.25∶0.52∶0.23),SEDDS粒径为(204±5)nm,乳化时间为(59±2)s。37℃时,SEDDS对隐丹参酮、丹参酮Ⅰ和丹参酮Ⅱ_A的最大载药量分别为5.075、3.397和6.559 mg/g,在水中的溶解度分别为0.138、0.238和0.367 mg/mL。结论:SEDDS对丹参酮类组分的增溶效果显著。
Objective:To explore the solubilization of self-emulsifying drug delivery system(SEDDS)for tanshinone muticomponents.Methods:With D-optimal mixture design to optimize SEDDS prescription,the contents of cryptotanshinone,tanshinone Ⅰ,tanshinone ⅡA and SEDDS particle size,emulsifying time were used as indicators to select and evaluate SEDDS.Results:The best SEDDS prescription was oleic acid∶Tween 20∶transcutol p(0.25∶0.52∶0.23),SEDDS particle size was(204±5)nm,emulsifying time was(59±2)s.At 37 ℃,the maximum loading capacities of SEDDS for cryptotanshinone,tanshinoneⅠ and tanshinone ⅡA were 5.075,3.397 and 6.559 mg/g,solubilities in water were 0.138,0.238 and 0.367 mg/mL,respectively.Conclusion:SEDDS can realize the solubilization of tanshinone muticomponents obviously.
作者
柯秀梅
徐良贤
黄浩洲
张定堃
韩丽
余文敏
刘频健
KE Xiu-mei;XU Liang-xian;HUANG Hao-zhou;ZHANG Ding-kun;HAN Li;YU Wen-min;LIU Pin-jian(Pharmacy College,Chengdu University of Traditional Chinese Medicine,Key Laboratory Breeding Base of Systematic Research and Utilizcition on Chinese Material Medical Krsourcrs Co-founded by Sichuan Province and Ministry of Science and Technology ,Chengdu 611137,China;Basic Medical College of Jiujiang University,Key Laboratoiy of Translational Medicine,Jiujiang 332000,China)
出处
《中药材》
CAS
北大核心
2018年第12期2871-2875,共5页
Journal of Chinese Medicinal Materials
基金
江西省科技厅项目(20181BAB215040)
江西省卫生厅项目(20173020).
关键词
自乳化释药系统
增溶
丹参酮
组分
D-最优混料设计
Self-emulsifying drug delivery system
Solubilization
Tanshinone
Multicomponent
D-optimal mixture design
