摘要
长链非编码RNA在多个层面(表观遗传学、转录水平、转录后水平)调控基因的表达,在机体发育及肿瘤的发生、发展过程中起着重要的作用。随着研究深入,发现LncRNA CRNDE是一种重要的癌症相关长链非编码RNA,了解LncRNA CRNDE在调节肿瘤细胞生命活动中的具体作用十分必要。近年来,有关LncRNA CRNDE在肿瘤发生发展中的作用研究不断增多,发现LncRNA CRNDE在多种肿瘤中表达上调,与肿瘤的增殖、侵袭转移和患者预后等密切相关,成为肿瘤研究的新热点。笔者结合国内外最新文献,围绕LncRNA CRNDE在消化系统肿瘤发生发展过程中的作用和机制作一综述,希望能为今后肿瘤的预防和治疗提供新的思路。
Long non-coding RNA regulates gene expression at multiple levels (epigenetics, transcriptional level, post-transcriptional level) and plays an important role in the development and progression of individual development and tumors. With the deep research, it is found that LncRNA CRNDE is an important cancer-related long non-coding RNA, and it is necessary to understand the specific role of LncRNA CRNDE in regulating tumor cell life activities. In recent years, the role of LncRNA CRNDE in tumorigenesis and development has been increasing. It has been found that LncRNA CRNDE is up-regulated in various tumors and is closely related to tumor proliferation, invasion, metastasis and patients′ prognosis, becoming a new hot spot in cancer research. The author combines the latest literatures at home and abroad to review the role and mechanism of LncRNA CRNDE in the development of digestive system tumors, hoping to prevent and treat tumors in the future.
作者
王嘉新
周原世
姜兴明
王微娜
Wang Jiaxin;Zhou Yuanshi;Jiang Xingming;Wang Weina(Department of Biliary and Pancreatic Surgery, The Second Affiliated Hospital of Harbin Medical University, Harbin 150086, China;Department of Anesthesiology, The Second Affiliated Hospital of Harbin Medical University, Harbin 150086, China)
出处
《中国医师杂志》
CAS
2019年第5期787-791,共5页
Journal of Chinese Physician
基金
国家自然科学基金(81602088)
中国博士后科学基金(2017M621305)
黑龙江省博士后科学基金(LBH-Z16096)
黑龙江省卫生计生委科研课题(2016-049)
哈尔滨医科大学创新科学研究基金(2016LCZX09)~~
关键词
消化系统肿瘤
RNA
长链非编码
基因表达调控
肿瘤
综述
Digestive system neoplasms
RNA, long noncoding
Gene expression regulation, neoplastic
Review
