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应用Opal和Mica构建数据统一与交流平台及探索信息共享模式 被引量:1

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摘要 近年来,流行病学和转化医学研究中不同项目之间的资源整合越来越广泛。资源的整合可运用于流行病学队列项目,也可运用于医院的临床信息[1-2]。这样的资源整合不用大规模地增加投入,就能满足统计分析所需的大样本量,极大地节约了研究经费和精力的投入[3]。
出处 《中国医药生物技术》 2019年第3期286-288,共3页 Chinese Medicinal Biotechnology
基金 国家国际科技合作专项(2014DFG31460) 国家科技资源共享服务平台计划项目(YCZYPT[2017]02)
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  • 1Winckelmans E, Cox B, Martens E, et al. Fetal growth and maternal exposure to particulate air pollution--More marked effects at lower exposure and modification by gestational duration. Environ Res, 2015, 140:611-618.
  • 2Manzano-Salgado CB, Casas M, Lopez-Espinosa MJ, et al. Transfer of perfluoroalkyl substances from mother to fetus in a Spanish birth cohort. Environ Res, 2015, 142:471-478.
  • 3Bebu I, Lachin JM. Large sample inference for a win ratio analysis of a composite outcome based on prioritized components. Biostatistics, 2015, pii:kxv032.
  • 4Howe D, Costanzo M, Fey P, et al. Big data: The future ofbiocuration. Nature, 2008, 455(7209):47-50.
  • 5Muilu J, Peltonen L, Litton JE. The federated database--a basis for biobank-based post-genome studies, integrating phenome and genome data from 600,000 twin pairs in Europe. Eur J Hum Genet, 2007, 15(7):718-723.
  • 6Doiron D, Burton P, Marcon Y, et al. Data harmonization and federated analysis of population-based studies: the BioSHaRE project. Emerg Themes Epidemiol, 2013, 10(1):12.
  • 7Pisani E, AbouZahr C. Sharing health data: good intentions are not enough. Bull World Health Organ, 2010, 88(6):462-466.
  • 8Jones EM, Sheehan NA, Masca N, et al. DataSHIELD -- shared individual-level analysis without sharing the data: a biostatistical perspective. Norsk Epidemiologi, 2012, 21 (2):231-239.
  • 9Fortier I, Burton PR, Robson P J, et al. Quality, quantity and harmony: the DataSHaPER approach to integrating data across bioclinical studies. Int J Epidemiol, 2010, 39(5): 1383-1393.
  • 10Smith-Warner SA, Spiegelman D, Ritz J, et al. Methods for pooling results of epidemiologic studies: the pooling project of prospective studies of diet and cancer. Am J Epidemiol, 2006, 163(11):1053- 1064.

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