摘要
目的:观察炎症因子(PCT、WBC、CRP)在急性一氧化碳中毒患者严重程度及预后预测方面的应用价值。方法:随机选取2016年4月-2018年4月笔者所在医院急救中心、按统一诊治标准收治的一氧化碳中毒患者130例进行研究,将其分为A组(轻度中毒)58、B组(中度中毒)41例、C组(重度中毒)31例。同时,选取同时间段门诊健康体检者40例,将其作为对照组进行对比研究。检查所有入选者PCT、WBC、CRP、APACHEⅡ评分、SOFA评分等情况。结果:病情严重程度与PCT水平比较差异无统计学意义(P>0.05),无相关性。病情严重程度与WBC、C反应蛋白水平为正相关关系(r=0.85、0.81,P<0.05)。不同病情严重程度患者的APACHEⅡ评分、SOFA评分相比差异有统计学意义(P<0.05),APACHEⅡ评分、SOFA评分与一氧化碳中毒轻、中、重度之间正相关(r=0.91、0.89,P<0.05)。不同病情严重程度患者的中毒、就诊、症状改善时间相比差异有统计学意义(P<0.05),中毒、就诊、症状改善时间与一氧化碳中毒轻、中、重度之间正相关(r=0.95、0.89、0.85,P<0.05)。结论:WBC、CRP水平、APACHEⅡ评分、SOFA评分及中毒、就诊、症状改善时间与中毒轻重情况正性相关。能够作为一氧化碳中毒的临床分级及预后预测的辅助指标,特别是在重症一氧化碳中毒患者评估治疗效果和预后方面,有一定参考价值。
Objective:To observe the value of inflammatory factor(PCT,WBC,CRP) in predicting the severity and prognosis of patients with acute carbon monoxide poisoning.Method:From April 2016 to April 2018,130 patients with carbon monoxide poisoning were randomly divided into group A(mild poisoningn,n=58) and group B(moderate poisoning,n=41),group C(severe poisoning,n=31) according to the standard of unified diagnosis and treatment.At the same time,40 cases of out-patient health check-up in the same period of time were selected as the control group for a comparative study.Check all candidates PCT,WBC,CRP,APACHEⅡ score,SOFA score and so on.Result:There was no significant difference among the severity of the disease and the level of PCT(P>0.05).There was a positive correlation between the severity of the disease and the level of WBC,CRP(r=0.85,0.81,P<0.05).The scores of APACHE Ⅱ and SOFA in patients with different severity were significantly different(P<0.05).Apache Ⅱ and SOFA scores were positively correlated with mild,moderate and severe carbon monoxide poisoning(r=0.91,0.89,P<0.05).Poisoning of patients with different severity of illness,there was a significant difference in poisoning,visiting,symptom improvement time between treatment and symptom improvement time(P<0.05).There was a positive correlation between poisoning,visiting,symptom improvement time and mild,moderate and severe carbon monoxide poisoning(r=0.95,0.89,0.85,P<0.05).Conclusion:The level of WBC,CRP,APACHEⅡ score,SOFA score and the time of symptom improvement are positively correlated with the severity of poisoning.It can be used as a supplementary index for clinical grading and prognosis prediction of carbon monoxide poisoning,especially in evaluating the therapeutic effect and prognosis of patients with severe carbon monoxide poisoning.
作者
景建军
张振贵
俞作发
沙瓦尔·妮莎
李剑峰
何光辉
JING Jianjun;ZHANG Zhengui;YU Zuofa(Shihezi People’s Hospital,Shihezi 832000,China)
出处
《中外医学研究》
2019年第15期1-3,共3页
CHINESE AND FOREIGN MEDICAL RESEARCH
基金
八师石河子市科技计划项目(项目编号:2017HZ17)
