摘要
目的观察将依诺肝素钠用不同混合方式加入到骨水泥中对其生物力学的影响。方法将注射用依诺肝素钠按照不同剂量、不同混合方式与聚甲基丙烯酸甲酯(PMMA)骨水泥进行混合,分为A组(空白对照组,不加入依诺肝素钠)、B组(8 000 AxaIU)、C组(16 000 AxaIU)、D组(24 000 AxaIU)作为对照组以粉粉混合方式加入,E组(8 000 AxaIU)、F组(16 000 AxaIU)、G组(24 000 AxaIU)作为实验组,将注射用依诺肝素钠溶解后再加入到PMMA骨水泥中。在无菌、温度(23±1)℃、相对湿度高于40%的环境下(手术室环境),制成骨水泥圆柱体标本及长方体标本。经测量及X线照射检测后选取每组标本各5个,于电子材料万能试验机上进行抗压强度、抗弯强度及抗弯模量的测定。结果实验组E、F、G组的抗压强度、抗弯强度及抗弯模量均明显低于对照组(t=12.731、41.646、3.128,P<0.05),差异有统计学意义,最低值分别为(57.17±1.15)MPa、(67.93±0.55)MPa、(19.2±0.114)GPa。结论依诺肝素钠以液体混合方式加入到PMMA骨水泥中会明显降低骨水泥的生物力学特性。
Objective To observe the biomechanical effects of enoxaparin sodium added to bone cement in different mixing modes.Methods The enoxaparin sodium for injection was mixed with polymethylmethacrylate(PMMA)bone cement according to different dosages and different mixing methods.Group A was used as blank control group without enoxaparin sodium.Groups B(8 000 AxaIU),C(16 000 AxaIU)and D(24 000 AxaIU)served as control groups in a powder mixture.Groups E(8 000 AxaIU),F(16 000 AxaIU)and G(24 000 AxaIU)served as experimental groups.The enoxaparin sodium for injection was dissolved and added to the PMMA bone cement.Under the environment of sterility,temperature(23±1)℃,relative humidity higher than 40%(operating room environment),according to the international standard ISO5833:2002"Implants for surgery-Acrylic resin cement"regulations,bone cement cylinder specimens and cuboid specimens were prepared.After measurement and X-ray irradiation,5 specimens of each group were selected,and the compressive strength,flexural strength and flexural modulus were measured on an electronic material universal testing machine.Results The compressive strength,flexural strength and flexural modulus in groups E,F and G were significantly lower than those in the control groups(t=12.731,41.646,3.128,P<0.05).The lowest values were(57.17±1.15)MPa,(67.93±0.55)MPa,and(19.2±0.114)GPa respectively.Conclusion The addition of enoxaparin sodium to PMMA bone cement in a liquid mixture can significantly reduce the biomechanical properties of bone cement.
作者
马新喆
齐向北
孙辉
李旭
徐国辉
李升
赵慧博
Ma Xinzhe;Qi Xiangbei;Sun Hui;Li Xu;Xu Guohui;Li Sheng;Zhao Huibo(Department of Orthopaedics,the Third Hospital of Xiangjiang Distict,Hebei Medical University,Shijiazhang 050035,China)
出处
《中华实验外科杂志》
CAS
CSCD
北大核心
2019年第5期933-935,共3页
Chinese Journal of Experimental Surgery
基金
河北省临床医学优秀人才培养和基础课题研究项目.
