摘要
目的探讨血清细胞角蛋白19片段(CYFRA21-1)、基质金属蛋白酶9(MMP-9)、甲状腺转录因子-1(TTF-1)水平在诊断肺恶性肿瘤的临床价值。方法选择2016年5月—2018年3月浙江省丽水市人民医院收治的27例肺恶性肿瘤患者、45例肺良性肿瘤患者及30例体检健康者作为研究对象,分别设为肺恶性肿瘤组、肺良性肿瘤组及健康对照组,采用电化学发光方法检测入选患者血清CYFRA21-1水平,采用酶联免疫吸附试验入选患者血清检测TTF-1、MMP-9水平。应用统计学方法比较差异。结果肺恶性肿瘤组的血清CYFRA21-1、MMP-9、TTF-1水平均明显高于良性肿瘤组和健康对照组,有统计学意义(P<0.05)。Logistic回归分析显示,CYFRA21-1、MMP-9、TTF-1与肺良性肿瘤均无相关性(P>0.01),与肺恶性肿瘤有相关性(P<0.01)。ROC曲线分析显示,血清CYFRA21-1诊断肺恶性肿瘤的AUC明显高于MMP-9和TTF-1,有统计学意义(P<0.05),MMP-9与TTF-1之间的AUC比较差异无统计学意义(P>0.05)。血清CYFRA21-1诊断肺恶性肿瘤敏感性、特异性分别为67.8%、93.1%;MMP-9诊断肺恶性肿瘤分别为42.1%、87.2%;TTF-1分别为44.3%、95.7%。结论血清CYFRA21-1、MMP-9、TTF-1水平在诊断肺恶性肺肿瘤方面具有一定的潜在价值,其中以CYFRA21-1最高。
Objective To explore the clinical value of cytokeratin 19 fragment(CYFRA21-1), matrix metalloproteinase 9(MMP-9) and thyroid transcription factor-1(TTF-1) in identifying benign and malignant lung tumors. Methods Twenty seven cases of malignant lung tumors, 45 cases of benign lung tumors, and 30 healthy subjects who were admitted to Lishui People’s Hospital of Zhejiang Province from March 2016 to May 2018 were selected and assigned into malignant tumor groups, benign tumors group and control group. The levels of CYFRA21-1 were detected by electrochemiluminescence and the levels of TTF-1 and MMP-9 were detected by enzyme-linked immunosorbent assay.Results The serum levels of CYFRA21-1, MMP-9 and TTF-1 in the malignant tumor group were significantly higher than those in the benign tumor group and the healthy control group, and the difference was statistically significant(all P<0.05). Logistic regression analysis showed that there was no correlation between CYFRA21-1, MMP-9 and TTF-1 and benign lung tumors(all P>0.01), which was correlated with malignant lung tumors(all P<0.01). ROC curve analysis showed that the AUC of serum CYFRA21-1 in differentiating benign and malignant lung tumors was significantly higher than that of MMP-9 and TTF-1, and the difference was statistically significant(all P<0.05), and there was no significant difference between MMP-9 and TTF-1(P>0.05). The sensitivity and specificity of serum CYFRA21-1 were 67.8%, 93.1%, of MMP-9 were 42.1% and 87.2%, and of TTF-1 were 44.3% and 95.7%, respectively. Conclusion The serum levels of CYFRA21-1, MMP-9 and TTF-1 have certain potential value in differential diagnosis of benign and malignant lung tumors, among which CYFRA21-1 is the highest.
作者
钱俊峰
徐芳
王洪源
曹卓
QIAN Jun-feng;XU Fang;WANG Hong-yuan(Department of Respiratory Medicine, Lishui Peoples Hospital, Lishui, Zhejiang 323000, China)
出处
《中华全科医学》
2019年第6期951-954,共4页
Chinese Journal of General Practice
基金
浙江省科技厅公益技术研究社会发展项目(2016C33243)
