摘要
目的:研究外敷中药夏治咳喘宁联合内服六味补气颗粒治疗COPD稳定期患者疗效评价。方法:选取2017年3月—6月期间在我院门诊及合作医院中医门诊辨治为肺肾气虚证COPD稳定期患者60例,随机划分治疗组(30例)与对照组(30例),治疗组给予模拟缓释型茶碱口服配合夏治咳喘宁外敷穴位+六味补气颗粒口服,对照组给予缓释型茶碱口服配合模拟夏治咳喘宁外敷穴位+口服六味补气颗粒模拟剂。结果:治疗结束时,中医症状疗效治疗组优于对照组(χ~2=4.320,P<0.05);干预治疗结束时治疗组住院平均天数、急性发作次数、CAT评分均少于对照组,统计学差异存在(P<0.05),随访第3个月时治疗组较对照组而言,统计学差异不明显(P>0.05);干预治疗结束时、随访第3个月时治疗组FEV1/FVC及促炎细胞因子IL-32血清浓度水平与对照组相比,统计学差异存在(P<0.05)。治疗结束时中医症状疗效治疗组优于对照组。结论:COPD稳定期患者接受中药夏治咳喘宁敷贴+口服六味补气颗粒治疗,效果胜于单一茶碱治疗,可以减少住院天数、急性发作次数、CAT评分,降低IL-32浓度水平,患者主要症状得以改善,生活质量相应提升。
Objective:To evaluate the efficacy of external application of Xiazhi Kechuanning combined with Liuwei Buqi Granule in the treatment of COPD patients at stable stage. Methods:From March to June 2017,60 COPD patients with lung and kidney Qi deficiency syndrome were selected. Patients were randomly divided into treatment group(30 cases)and control group(30 cases). The treatment group was treated with simulated slow-release theophylline orally combined with Xiazhi Kechuanning external application of acupoint Liuwei Buqi Granule. The control group was treated with slow-release theophylline combined with simulated Xiazhi Kechuanning external application. Results:TCM symptoms at the end of treatment,the treatment group was better than the control group(χ^2=4.320,P<0.05);the average days of hospitalization,the times of acute attack and the CAT score of the treatment group were lower than those of the control group at the end of the intervention treatment group(P<0.05),at the third month of follow-up, there was no significant difference between the treatment group and the control group(P>0.05). There was significant difference in serum levels of FEV1/FVC and pro-inflammatory cytokines(IL-32)between the treatment group and the control group at the end of intervention(P<0.05). The curative effect of TCM symptom at the end of treatment was better than that of control group. Conclusion:The patients with COPD at stable stage were treated with Xiazhi Kechuanning oral application of Liuwei Buqi Granule,the effect was better than that of single theophylline therapy,which could reduce the days of hospitalization,the times of acute attack,the CAT score and the level of IL-32. The main symptoms of the patients were improved and the quality of life was improved accordingly.
作者
汪丹阳
董昌武
李泽庚
张至强
童佳兵
李达
WANG Danyang;DONG Changwu;LI Zegeng;ZHANG Zhiqiang;TONG Jiabing;LI Da(Anhui University of Chinese Medicine,Hefei 230031,Anhui,China;Anhui Academy of Chinese Medicine Sciences,Hefei 230012,Anhui,China;First Affiliated Hospital of Anhui University of Traditional Chinese Medicine,Hefei 230031,Anhui,China;First People’s Hospital of Hefei,Hefei 230032,Anhui,China)
出处
《辽宁中医药大学学报》
CAS
2019年第5期87-90,共4页
Journal of Liaoning University of Traditional Chinese Medicine
基金
国家自然科学基金资助项目(81804039
81874431)
合肥市科技局"借转补"资助项目[合科(2016)89]
关键词
冬病夏治
穴位敷贴
COPD稳定期
肺肾气虚证
winter disease and summer treatment
acupoint application
COPD stable period
lung and kidney Qi deficiency syndrome
