摘要
脑卒中严重危害人类的生命和健康,是成年人致残的主要原因,也是我国最常见的慢性病之一。脑卒中不仅严重损伤大脑灰质,还严重损伤白质。以往更加注重对大脑灰质的研究,而不够重视对白质损伤的作用,但在治疗上来看,就算灰质从损伤中恢复,而未对白质的损伤进行及时挽救,患者的治疗难以取得理想的效果。故应更加重视对白质损伤机制的深入理解,及时尽量恢复白质的功能。少突胶质细胞是脑白质的主要构成部分,对缺血性损伤极为敏感,保护少突胶质细胞免受缺血损伤及促进少突胶质细胞再生是维护缺血性卒中后白质完整性的重要手段。本文就白质损伤及保护的研究进展展开综述。
Stroke seriously endanger human life and health, is the main cause of disability in adults, but also one of the most common chronic diseases in our country. Stroke is not only serious damage to the brain gray matter, but also seriously damage the white matter. In the past, more attention was paid to the study of the gray matter of the brain, not to the importance of white matter damage. However, even if the gray matter is recovered from the injury and the white matter is not salvaged in time, the treatment of the patient is hard to achieve the desired effect. Therefore, more attention should be paid to the white matter damage mechanism in-depth understanding of the timely recovery of white matter function. Oligodendrocytes are a major component of white matter and are extremely sensitive to ischemic injury. Protecting oligodendrocytes from ischemic injury and promoting oligodendrocyte regeneration is essential for the maintenance of white matter integrity after ischemic stroke The important means. This article reviews the research progress of white matter damage and protection.
作者
季宇彬
邵钰莹
王群
郭安臣
JI Yu-bin;SHAO Yu-ying;WANG Qun;GUO An-chen(Center for Life Science and Environmental Sciences,Harbin University of Commerce,Harbin 150076,China;Beijing Institute of Brain Diseases,Beijing 100069,China;Beijing Tiantan Hospital,Capital Medical University,Beijing 100050,China;National Center for Clinical Research of Nervous System Diseases,Beijing 100076;Beijing Key Laboratory of Cerebrovascular Disease Translational Medicine,Beijing 100076,China)
出处
《中国医药指南》
2019年第13期33-36,共4页
Guide of China Medicine
基金
国家重点研发计划资助(项目编号:2017YFC1307500)
关键词
脑卒中
白质损伤
白质保护
少突胶质细胞
Stroke
White matter injury
White matter protection
Oligodendrocyte
