摘要
目的探讨特利加压素与奥曲肽在肝硬化上消化道出血患者中的应用效果。方法选取2016年1月—2018年12月我院收治的80例肝硬化上消化道出血患者随机分为观察组(40例)和对照组(40例);对照组采用基础治疗+艾司奥美拉唑+奥曲肽,观察组在对照组基础上加用特利加压素;对两组疗效、止血效果、48 h再出血率及不良反应发生情况进行对比分析。结果观察组治疗总有效率高于对照组(P<0.05);观察组止血时间、输血量、48 h再出血率低于对照组(P<0.05),观察组血红蛋白水平及24 h止血率高于对照组(P <0.05);两组不良反应发生率差异无统计学意义(P> 0.05)。结论与奥曲肽单独用药相比,联用特利加压素与奥曲肽治疗肝硬化上消化道出血在不增加不良反应的同时可显著提高止血效果和治疗效果,同时还可降低48 h再出血率。
Objective To explore the clinical effect of terlipressin and octreotide for upper gastrointestinal bleeding accompanied by hepatic cirrhosis.Methods 80 cases of upper gastrointestinal bleeding accompanied by hepatic cirrhosis from January 2016 to December 2018 were selected and divided into observation group (n =40) and control group (n =40) randomly.The control group was taken routine treatment,esomeprazole and octreotide.The observation group was taken terlipressin based on control group.The clinical effects,hemostatic effects,rebleeding rate in 48 h and adverse reactions in the two groups were compared.Results The total effective rate of the observation group was higher than that of the control group (P < 0.05).The hemostasis time,blood transfusion volume and 48 h rebleeding rate in the observation group were lower than those in the control group (P < 0.05).The hemoglobin level and 24-hour hemostasis rate in the observation group were higher than those in the control group (P < 0.05).There was no significant difference in the incidence of adverse reactions between the two groups (P > 0.05).Conclusion Compared with octreotide,the combination of terlipressin and octreotide can improve hemostatic and clinical effects with lower rebleeding rate in 48 h for upper gastrointestinal bleeding accompanied by hepatic cirrhosis.
作者
曾以琳
ZENG Yilin(Department of Gastroenterology,The First Hospital ofQuanzhou,Quanzhou Fujian 362200,China)
出处
《中国卫生标准管理》
2019年第7期66-69,共4页
China Health Standard Management
关键词
肝硬化
上消化道出血
奥曲肽
特利加压素
疗效
安全性
hepatic cirrhosis
upper gastrointestinal haemorrhage
octreotide
terlipressin
effect
security
