摘要
阿片类药物成瘾发生率高,对个人和社会危害极大。中脑边缘奖赏系统在阿片类药物成瘾中发挥着重要作用,以往研究多集中于中脑边缘奖赏系统中特定脑区的功能变化,而对脑区之间神经元的相互作用研究较少。该文对近年来中脑边缘奖赏系统参与阿片类药物成瘾的环路机制进行综述,以期从更广阔的视野了解阿片类药物成瘾机制。
Opioid addiction has high incidence and does great harm to individuals and society.The mesolimbic reward system plays an important role in opioid addiction.Previous studies have focused on functional adaptations in specific brain regions of the mesolimbic reward system,but the neuronal interactions in mesolimbic reward system underlying opioid addiction remain unknown.The paper reviews the neural circuit mechanisms in mesolimbic reward system involved in opioid addiction,in order to provide a broader vision for understanding the mechanisms of opioid addiction.
作者
孙国林
张咏梅
SUN Guo-lin;ZHANG Yong-mei(Jiangsu Province Key Lab of Anesthesiology,Jiangsu Province Key Lab of Anesthesia andAnalgesia Application Technology,Xuzhou Medical University,Xuzhou Jiangsu221004,China)
出处
《中国药理学通报》
CAS
CSCD
北大核心
2019年第5期611-614,共4页
Chinese Pharmacological Bulletin
基金
国家自然科学基金资助项目(No 81771203
81772065)
江苏省自然科学基金资助项目(No BK20161171)
