摘要
肠道微生物可以介导神经、内分泌、免疫、代谢等途径,与大脑进行双向调节作用,这种相互作用的通道被称为微生物-肠-脑轴。越来越多研究表明,肠道微生物的结构和多样性影响着宿主神经系统疾病,包括抑郁症、帕金森病和阿尔茨海默病。异常的肠道微生物结构可以引起疾病的发生、发展,而合适的微生物群可以预防和治疗疾病。该文对肠道微生物多样性与部分神经系统疾病的相关性进行综述,以期为疾病的治疗提供新的思路和方法。
Gut microbiota can interact with the brain through neuronal,endocrine,immune and metabolic pathways.This interaction is called the microbiota-gut-brain axis.Increasing studies have demonstrated that the structure and diversity of gut microbes can influence host neurological diseases,including depression,Parkinson's disease and Alzheimer's disease.Abnormal gut microbial structures may cause disease,while appropriate microbiome prevents and cures disease.This article reviews the correlation between gut microbial diversity and some neurological diseases in order to provide new ideas and methods for the treatment of these diseases.
作者
张银
闻俊
周婷婷
ZHANG Yin;WEN Jun;ZHOU Ting-ting(School of Pharmacy,the Second Military Medical University,Shanghai KeyLab for Pharmaceutical Metabolites Research,Shanghai200433,China)
出处
《中国药理学通报》
CAS
CSCD
北大核心
2019年第5期597-602,共6页
Chinese Pharmacological Bulletin
基金
国家自然科学基金资助项目(No 81773862
81573584)
