摘要
MicroRNAs(miRNAs)调控作为表观遗传学的重要组成部分,可调节人类基因组中约60%的蛋白质编码基因,参与调节着生物体的生长发育、细胞增殖和凋亡、脂肪代谢、病毒免疫等诸多方面。迄今为止,有大量研究探索了异常表达的miRNAs与多种肝脏疾病的高度相关性,本文就对近年来miRNAs在乙型病毒性肝炎、非酒精性脂肪性肝病、肝纤维化、肝硬化、肝癌中的作用机制及变化特点等相关研究进行综述。
As an important part of epigenetics,microRNAs can regulate about 60%of protein-coding genes in human genome,and participate in the regulation of growth and development,cell proliferation and apoptosis,fat metabolism,viral immunity and so on.So far,a large number of studies have explored the high correlation between abnormally expressed microRNAs and various liver diseases.This article reviews the recent studies on the mechanism and characteristics of microRNAs in viral hepatitis B,non-alcoholic fatty liver disease,liver fibrosis,cirrhosis and hepatocellular carcinoma.
作者
张帅
刘迎娣
孙国辉
王娟
何占娣
Zhang Shuai;Liu Yingdi;Sun Guohui;Wang Juan;He Zhandi(Department of Gastroenterology,the First Medical Center of Chinese PLA General Hospital,Beijing 100853,China)
出处
《中华胃肠内镜电子杂志》
2019年第1期32-36,共5页
Chinese Journal of Gastrointestinal Endoscopy(Electronic Edition)
