摘要
目的:探讨依达拉奉联合脑苷肌肽治疗重症颅脑损伤的疗效及对患者氧化应激和神经功能的影响。方法:选取2016年5月至2018年3月灵宝市第一人民医院收治的重症颅脑损伤患者146例,依据随机数字表法分为观察组和对照组,每组73例。对照组患者在常规治疗的基础上给予脑苷肌肽,观察组患者在对照组的基础上加用依达拉奉。比较两组患者的氧化应激指标水平[丙二醛(MDA)、髓过氧化物酶(MPO)、超氧化物歧化酶(SOD)和谷胱甘肽过氧化物酶(GSH-Px)]、神经功能指标水平[脑钠肽(BNP)、胶质原纤维酸性蛋白(GFAP)和神经元特异性烯醇化酶(NSE)]及临床疗效的差异。结果:治疗后,观察组患者MDA、MPO水平较治疗前明显降低,SOD、GSH-Px水平较治疗前明显升高;且观察组患者上述指标水平明显优于对照组,差异均有统计学意义(P<0.05);治疗后,观察组患者BNP水平较治疗前明显升高,GFAP、NSE水平较治疗前明显降低;且观察组患者上述指标水平明显优于对照组,差异均有统计学意义(P<0.05);观察组患者的总有效率为94.5%(69/73),明显高于对照组的76.7%(56/73),差异有统计学意义(P<0.05)。结论:依达拉奉联合脑苷肌肽治疗重症颅脑损伤的疗效良好,可抑制机体氧化应激水平,利于患者神经功能的恢复。
OBJECTIVE: To probe into the efficacy of edaravone combined with cerebroside carnosine in treatment of severe craniocerebral injury and its effects on patients’ oxidative stress and neurological function. METHODS: 146 patients with severe craniocerebral injury admitted into the First People’s Hospital of Lingbao from May 2016 to Mar. 2018 were selected and divided into observation group and control group via random number table, with 73 cases in each group. The control group was treated with cerebroside carnosine based on conventional therapy, while the observation group was given edaravone based on the control group. Differences in oxidative stress indices [malondialdehyde(MDA), myeloperoxidase(MPO), superoxide dismutase(SOD)and glutathione peroxidase(GSH-Px)], neurological function indices [brain natriuretic peptide(BNP), glial fibrillary acidic protein(GFAP)and neuron-specific enolase(NSE)] and clinical efficacy between two groups were compared. RESULTS: After treatment, the MDA and MPO levels of observation group were significantly lower than those of before treatment, with significantly increased SOD and GSH-Px levels;and these indices of observation group were significantly better than the control group, with statistically significant differences(P<0.05);after treatment, the BNP level of observation group was significantly higher than that of before treatment, with significantly decreased GFAP and NSE levels, and these indices of observation group were significantly better than the control group, with statistically significant differences(P<0.05);the total effective rate of observation group was 94.5%(69/73), which was significantly higher than that of the control group(76.7%, 56/73), with statistically significant difference(P<0.05). CONCLUSIONS: The efficacy of edaravone combined with cerebroside carnosine in treatment of severe craniocerebral injury is remarkable, which can inhibit oxidative stress and facilitate the recovery of neurological function.
作者
马奔
张岩平
王锐
李向军
MA Ben;ZHANG Yanping;WANG Rui;LI Xiangjun(Dept.of Neurosurgery,the First People’s Hospital of Lingbao,Henan Lingbao 472500,China)
出处
《中国医院用药评价与分析》
2019年第3期317-319,共3页
Evaluation and Analysis of Drug-use in Hospitals of China
关键词
依达拉奉
脑苷肌肽
重症颅脑损伤
氧化应激
神经功能
Edaravone
Cerebroside carnosine
Severe craniocerebral injury
Oxidative stress
Neurological function
