摘要
目的:探讨丙泊酚复合舒芬太尼用于重型颅脑损伤患者术后镇静镇痛的临床效果。方法:选取2015年9月至2018年11月柳州市人民医院收治的重型颅脑损伤患者166例,采用动态随机法分为观察组与对照组,每组83例。观察组患者给予舒芬太尼复合丙泊酚,对照组患者给予单一舒芬太尼。比较两组患者的镇静躁动评分(sedation and agitation scale,SAS)、疼痛视觉模拟评分(visual analogue scale,VAS)、体温、心率、平均动脉压及颈静脉血氧饱和度的差异。结果:术后1 h,两组患者SAS评分、VAS评分的差异均无统计学意义(P>0.05);术后2 h,观察组患者SAS评分、VAS评分明显低于对照组,差异均有统计学意义(P<0.05)。治疗后,两组患者体温、心率、平均动脉压及颈静脉血氧饱和度的差异均无统计学意义(P>0.05)。结论:舒芬太尼复合丙泊酚可有效减少重型颅脑损伤患者的疼痛感,改善预后。
OBJECTIVE: To probe into the clinical effect of propofol combined with sufentanil on postoperative sedation and analgesia in patients with severe craniocerebral injury. METHODS: 166 patients with severe craniocerebral injury admitted into Liuzhou People’s Hospital from Sept. 2015 to Nov. 2018 were selected and divided into observation group and control group via dynamic stochastic method, with 83 cases in each group. The observation group was given sufentanil combined with propofol, the control group was treated with sufentanil alone. Differences in scores of Sedation and Agitation Scale(SAS), scores of Visual Analogue Scale(VAS), body temperature, heart rates, mean arterial pressure and jugular venous oxygen saturation between two groups were compared. RESULTS: At 1 h after operation, there were no statistically significant differences in SAS scores and VAS scores between both groups(P>0.05);at 2 h after operation, the SAS scores and VAS scores of observation group were significantly lower than those of the control group, with statistically significant differences(P<0.05). After treatment, there were no statistical significance in differences in body temperature, heart rates, mean arterial pressure and jugular venous oxygen saturation between two groups(P>0.05). CONCLUSIONS: The combination of sufentanil and propofol can effectively reduce pain for patients with severe craniocerebral injury and improve prognosis.
作者
覃月佳
张友华
郑伟钢
QIN Yuejia;ZHANG Youhua;ZHENG Weigang(Dept.of ICU,Liuzhou People’s Hospital,Guangxi Liuzhou 545000,China)
出处
《中国医院用药评价与分析》
2019年第3期281-282,286,共3页
Evaluation and Analysis of Drug-use in Hospitals of China
基金
广西壮族自治区卫生和计划生育委员会自筹经费科研项目(No.Z20170702)
关键词
重型颅脑损伤
舒芬太尼
丙泊酚
镇静镇痛
临床效果
Severe craniocerebral injury
Sufentanil
Propofol
Sedation and analgesia
Clinical effect
