摘要
层状双氢氧化物LDH作为拥有特殊层状结构的纳米药物载体,具有低毒性、可降解性以及药物缓释的性能。因此,设计合成了具有可降解的低毒性靶向药物缓释系统LDH/HA-PEG/5-FU。为了使药物递送系统LDH/HA-PEG/5-FU获得最大载药量,采用控制变量法测定了在不同的反应时间、反应温度以及不同的HA-PEG投放浓度下LDH/HA-PEG/5-FU的药物包封率、zeta电位及粒径,最终得出一步法合成LDH/HA-PEG/5-FU的最优反应条件为,恒温水浴70℃,反应时间24 h,加入浓度为1 mg/mL的HA-PEG分散液,在上述条件下合成的药物递送体系LDH/HA-PEG/5-FU可获得最高载药量。
The layered double hydroxide LDH is one kind of nano drug carriers which have special layered structure,low toxicity,degradability and sustained drug release property.In our study,a low toxicity targeted drug release system LDH/HA-PEG/5-FU with fine degradability was synthesized.In order to obtain the maximum drug loading for the system LDH/HA-PEG/5-FU,the control variable method was used to detect the encapsulation efficiency,zeta potential and particle size of LDH/HA-PEG/5-FU at different reaction times,different reaction temperatures and different concentrations of HA-PEG.Finally,the optimal reaction condition for one-method synthesis of LDH/HA-PEG/5-FU was obtained:thermostatic waterbath of 70℃,24 h of reaction time and1 mg/mL of the concentration of HA-PEG.The drug delivery system of LDH/HA-PEG/5-FU synthesized under the above conditions was able to obtain the maximum drug loading.
作者
李雪
刁海鹏
王浩江
李丽红
董岸杰
LI Xue;DIAO Haipeng;WANG Haojiang;LI Lihong;DONG Anjie(School of Basic Medicine,Shanxi Medical University,Taiyuan 030001,China;School of Chemical Engineering,Tianjin University,Tianjin 300000,China)
出处
《功能材料》
EI
CAS
CSCD
北大核心
2019年第4期4197-4200,4206,共5页
Journal of Functional Materials
基金
国家自然科学基金资助项目(21705104)
山西医科大学博士启动基金资助项目(03201601)
关键词
纳米药物载体
层状双氢氧化物
载药量
控制变量法
合成条件
nano-drug carrier
layered double hydroxide
drug loading capacity
control variable method
synthesis conditions
