摘要
目的探究瑞芬太尼联合丙泊酚用于脑出血微创引流术的麻醉效果。方法随机选取2016年1月至2018年4月在我院行脑出血微创引流术的患者50例,根据患者入院顺序单双号将其分为试验组与对照组,每组25例。对照组采用芬太尼联合丙泊酚麻醉,试验组采用瑞芬太尼联合丙泊酚麻醉。观察两组患者醉诱导前(T1)、麻醉诱导后(T2)、穿刺钻孔后(T3)、术后(T4)的心率、舒张压、收缩压、不良反应发生情况、丙泊酚用量、自主呼吸恢复所用时间。结果 T1时,两组的心率、舒张压、收缩压比较,差异无统计学意义(P>0.05);T2、T3、T4时,试验组患者的心率、舒张压、收缩压均优于对照组,差异具有统计学意义(P<0.05);试验组患者的不良反应总发生率低于对照组,差异具有统计学意义(P<0.05);试验组患者的丙泊酚用量少于对照组,自主呼吸恢复所需时间短于对照组,差异具有统计学意义(P<0.05)。结论行脑出血微创引流术的患者采用瑞芬太尼联合丙泊酚麻醉不仅利于维持术中心率、血压,更利于减少丙泊酚使用量,进而降低不良反应发生率,值得临床推广应用。
Objective To explore the anesthetic effect of remifentanil combined with propofol for minimally invasive drainage of cerebral hemorrhage. Methods From January 2016 to April 2018, 50 patients undergoing minimally invasive drainage of intracerebral hemorrhage in our hospital were randomly selected and divided into experimental group and control group according to the single and double numbers of admission order, with 25 cases in each group. The control group was anesthetized with fentanyl and propofol, the experimental group was anesthetized with remifentanil and propofol. The heart rates, diastolic blood pressure, systolic blood pressure before intoxication induction(T1), after intoxication induction(T2), after puncture and drilling(T3) and after operation(T4), adverse reactions, propofol dosage and time of spontaneous breathing recovery in the two groups were observed. Results There were no significant differences in heart rates, diastolic blood pressure and systolic blood pressure between the two groups at T1(P >0.05).The heart rates, diastolic blood pressure and systolic blood pressure in the experimental group were better than those in the control group at T2, T3, T4, the differences were statistically significant(P <0.05). The total incidence of adverse reactions in the experimental group was lower than that in the control group, the difference was statistically significant(P <0.05). The dosage of propofol in the experimental group was less than that in the control group, the time of spontaneous breathing recovery in the experimental group was shorter than that in the control group, the differences were statistically significant(P <0.05). Conclusion Remifentanil combined with propofol anesthesia in patients undergoing minimally invasive drainage of intracerebral hemorrhage is not only conducive to maintaining intraoperative heart rate and blood pressure, but also conducive to reducing the dosage of propofol, thereby decreasing the incidence of adverse reactions, which is worthy of clinical application and popularization.
作者
蒋延安
付华君
孟娟
赵静
JIANG Yan-an;FU Hua-jun;MENG Juan;ZHAO Jing(Shaanxi Provincal People's Hospital, Xi'an 710068, China)
出处
《临床医学研究与实践》
2019年第11期42-44,共3页
Clinical Research and Practice
关键词
瑞芬太尼
丙泊酚
脑出血
微创引流术
麻醉
remifentanil
propofol
cerebral hemorrhage
minimally invasive drainage
anesthesia
