摘要
目的研究无创呼吸机配合沙美特罗替卡松粉剂吸入治疗慢性阻塞性肺疾病急性加重(AECOPD)并发呼吸衰竭的疗效及对患者预后生存质量的影响。方法选择2017年1月至2018年8月于本院接受诊治的AECOPD并发呼吸衰竭患者106例进行观察研究,参照随机数表法分成对照组、研究组,各53例。对照组患者采用无创呼吸机治疗,研究组患者采用无创呼吸机联合沙美特罗替卡松粉剂吸入治疗。对比2组患者治疗前后肺功能、动脉血气指标变化及预后生存质量。结果治疗后2组患者的肺功能指标第1秒用力呼气容积(FEV_1)、用力肺活量(FVC)、FEV_1/FVC、6 min步行距离(6MWD)高于对照组,差异有统计学意义(P<0.05);相较于治疗前,治疗后2组患者的动脉血氧分压(PaO_2)值升高,且动脉血二氧化碳分压(PaCO_2)值降低,差异有统计学意义(P<0.05);2组PaO_2、PaCO_2比较,差异有统计学意义(P<0.05);治疗后2组患者生存质量评分升高,差异有统计学意义(P<0.05)。结论无创呼吸机联合沙美特罗替卡松粉剂吸入治疗AECOPD并发呼吸衰竭疗效显著,能有效缓解临床症状与体征,改善患者的肺功能及动脉血气,提高患者生存质量。
Objective To determine the efficacy of non-invasive ventilator combined with salmeterol-fluticasone inhalation on te exacerbation of chronic obstructive pulmonary disease (AECOPD) complicated with respiratory failure and its effect on prognostic quality of life (QOL). Methods A total of 106 patients with AECOPD complicated with respiratory failure admitted to our hospital between January 2017 and August 2018 were included in the study, and randomly divided into the control group and study group (n=53 each). The control group was treated with noninvasive ventilator, and the study group was treated with non-invasive ventilator combined with salmeterol-fluticasone powder. The lung function, arterial blood gas index and prognostic QOL in the two groups were compared before and after treatment. Results After the treatment, the levels of lung function indexes, FEV1, FVC, FEV1/FVC, 6MWD and PaO2 in the study group were higher than those in the control group(all P<0.05). The PaCO2 level in the study group was lower than that in the control group(P<0.05). After the treatment, the QOL score in the two groups increased. The QOL score in the study group was higher than that in the control group(P<0.05). Conclusion Non-invasive ventilator combined with salmeterol-fluticasone powder in the treatment of AECOPD complicated with respiratory failure is significantly effective. It may effectively alleviate clinical symptoms and signs, improve lung function and arterial blood gas, and promote QOL.
作者
聂言臣
张特
王宗立
Nie Yanchen;Zhang Te;Wang Zongli(Department of Respiratory,Huzhou Sixth Municipal Hospital,Zhejiang 313000,China)
出处
《中国药物与临床》
CAS
2019年第8期1229-1231,共3页
Chinese Remedies & Clinics
基金
浙江省湖州市科技局项目(2016GYB23)
关键词
肺疾病
慢性阻塞性
通气机
负压
呼吸功能不全
预后
沙美特罗替卡松粉剂
Pulmonary disease,chronic obstructive
Ventilators,negative-pressure
Respiratory insufficiency
Prognosis
Salmeterol-fluticasone powder
