摘要
目的:观察膈下逐瘀汤联合吉西他滨对胰腺癌患者细胞免疫功能、血清癌胚抗原(CEA)、糖类抗原199(CA199)、自然杀伤T细胞(NKT)水平的影响。方法:将102例胰腺癌患者随机分为对照组和治疗组各51例。两组患者均给予健康教育、饮食、运动等基础干预,在此基础上对照组患者给予吉西他滨治疗,治疗组患者在对照组基础上予膈下逐瘀汤治疗。观察两组患者中医证候积分、免疫功能、临床疗效,检测血清CEA、CA199、NKT水平,统计不良反应发生率。结果:治疗后两组患者中医证候积分均较治疗前低(P<0.05),且治疗组患者治疗后中医证候积分低于对照组(P<0.05);治疗后对照组患者CD3^+、CD4^+、CD4^+/CD8^+较治疗前降低,CD8^+较治疗前升高,而治疗组患者治疗后CD3^+、CD4^+、CD8^+、CD4^+/CD8^+与治疗前比较,差异均无统计学意义(P>0.05),且治疗组患者治疗后CD3^+、CD4^+、CD4^+/CD8^+高于对照组,CD8^+低于对照组(P<0.05)。治疗组总有效率(68.63%)明显高于对照组(47.06%),差异有统计学意义(P<0.05)。治疗后两组患者CEA、CA199水平较治疗前降低,NKT水平较治疗前升高(P<0.05),且治疗组患者治疗后CEA、CA199水平低于对照组,NKT水平高于对照组(P<0.05);治疗组患者肝功能异常、骨髓抑制、血小板减少、恶心呕吐、白细胞减少发生率均低于对照组(P<0.05)。结论:膈下逐瘀汤联合吉西他滨可有效提高胰腺癌患者免疫功能,改善血清CEA、CA199、NKT水平,提高临床疗效。
Objective: To observe the effect of infradiaphragmatic stasis -expelling decoction combined with gemcitabine on cellular immune function, serum carcinoembryonic antigen (CEA), CA199, natural killer T cell (NKT) levels of patients with pancreatic cancer. Methods: 102 patients with pancreatic cancer were divided into control group and observation group randomly, 51 cases in each group. All the two groups were given basic in-tervention, such as health education, diet and exercise, on the basis of that, the control group were given gemc-itabine treatment, and the observation group were combined with infradiaphragmatic stasis-expelling decoction on the basis of the control group. TCM symptom scores, immune function and clinical efficacy were observed, serum CEA, CA199 and NKT levels were detected, and the incidence of adverse reactions was figured in the two groups. Results: After treatment, the TCM syndrome scores of the two groups were lower than those before treatment (P<0.05), and the observation group was lower than that of the control group (P<0.05). After treatment, CD3^+, CD4^+ and CD4^+/CD8^+ of the control group were lower than before treatment, and CD8^+ was higher than before treatment, but the differences of GD3^+, CD4^+ and CD4^+/CD8^+ in the observation group were not statistical-ly significant (P>0.05), and the CD3^+, CD4^+ and CD4^+/CD8^+ in the observation group were higher than those of the control group, which was lower than the control group (P<0.05). The total effective rate of the observation group was 68.63%, which was significantly better than that of the control group 47.06%(P<0.05). After treat-ment, the level of CEA and CA199 in the two groups was lower than that before the treatment, and the level of NKT was higher than that before the treatment (P<0.05), and the level of CEA and CA199 in the observation group was lower than that in the control group, and the level of NKT was higher than that of the control group (P<0.05). The incidence of liver dysfunction, bone marrow suppression, thrombocytopenia, nausea and vomiting, and leukocyte reduction in the observation group were lower than those in the control group (P<0.05). Conclusion: Infradiaphragmatic stasis-expelling decoction combined with gemcitabine can effectively improve immune function of patients with pancreatic cancer, and can improve serum CEA, CA199 and NKT levels and the clinical efficacy.
作者
冯晓飞
周禄荣
金迎
宋文杰
FENG Xiao-fei;ZHOU Lu-rong;JIN Ying;SONG Wen-jie(The Second Affiliated Hospital of Liaoning University of Chinese Medicine/Liaoning Academy of Traditional Chinese Medicine, Shenyang Liaoning 110034, China)
出处
《中医药导报》
2019年第6期53-56,共4页
Guiding Journal of Traditional Chinese Medicine and Pharmacy
基金
辽宁省科技攻关计划项目(2016221089)
关键词
胰腺癌
膈下逐瘀汤
吉西他滨
免疫功能
临床观察
pancreatic cancer
infradiaphragmatic stasis -expelling decoction
gemcitabine
immune function
clinical observation
