摘要
目的研究解磷注射液在有机磷农药中毒急救中的应用效果。方法选取2010年3月—2017年3月我院收治的有机磷农药中毒急救患者167例,按照随机数字表法分为试验组84例与对照组83例。对照组予以常规方法治疗,试验组则在对照组的基础上加用解磷注射液。比较2组疗效,症状消失时间、辅助呼吸时间以及住院时间,治疗1 d、5 d、10 d后胆碱酯酶活性,不良反应发生情况。结果试验组治疗总有效率为97.62%(82/84),明显高于对照组的80.72%(67/83),差异有统计学意义(P<0.05)。试验组患者症状消失时间、辅助呼吸时间以及住院时间分别为(1.02±0.33)h、(16.24±10.31)h、(5.20±2.33)d,均明显低于对照组的(13.27±4.02)h、(22.74±11.23)h、(11.74±3.05)d,差异有统计学意义(P<0.05)。治疗5 d、10 d后试验组患者胆碱酯酶活性分别为(878.38±108.97)IU/L、(2 973.24±322.42)IU/L,均明显高于对照组的(735.72±87.50)IU/L、(1 847.87±273.68)IU/L,差异有统计学意义(P<0.05)。试验组患者不良反应发生率为3.57%(3/84),明显低于对照组的13.25%(11/83),差异有统计学意义(P<0.05)。结论解磷注射液应用于有机磷农药中毒急救过程中的效果明显,可有效改善胆碱酯酶活性,降低不良反应发生率,安全性较好,有利于促进患者早日康复,值得临床推广应用。
Objective To observe and evaluate the clinical efficacy of valsartan combined with hydrochlorothiazide in the treatment of hypertensive heart disease patients.Methods 116 cases of hypertensive heart disease in the hospital from October 2016 to 2017 were selected and divided into the experimental group (57cases) and the control group (59 cases ).The patients in the experimental group were treated with valsartan and hydrochlorothiazide, and the control group was treated by valsartan.After the treatment, the patients were compared and analyzed.The two groups of patients were clinically effective.Results After treatment, the total effective rate and the change of LVH in the experimental group were significantly better than those in the control group (P<0.05).Objective To study the phosphate dissolving injection in the emergency treatment of organophosphorus pesticide poisoning.Methods 167 organophosphorus pesticides were selected from March 2010 to March 2017 with emergency cases in our hospital.They were randomLy divided into test group and control group, 83 cases in the control group, 84 cases in the test group.The control group was given routine treatment, the test group based on the control group with phosphate dissolving injection treatment.Curative effect between the two groups, the symptoms disappeared time,ventilation time and hospitalization time,after the treatment of ld,5d and lOd after cholinesterase activity, the occurrence of adverse reactions was compared.Results The test group of total effective rate was 97.62%(82/84), significantly higher than the control group 80.72%(67/83 ), there was statistical significance between the groups (P<0.05 ).The test group of patients with symptoms disappeared time, ventilation time and hospitalization time were (1.02±0.33 ) h,(16.24±10.31) h,(5.20±2.33) d, were significantly lower than the control group (13.27±4.02) h,(22.74±11.23 ) h,( 1 1.74±3.05) d,there was statistical significance between the groups (P<0.05 ).After 5d, lOd treatment patients in test group of cholinesterase activity were (878.38±108.97 ) IU/L,( 2 973.24±322.42) IU/L,which were significantly higher than those in control group (735.72±87.50) IU/L,( 1847.87±273.68 ) IU/L,there was statistical significance between the groups (P<0.05 ).After treatment, the incidence of adverse reactions in the test group was 3.57%(3/84), significantly lower than 13.25%( 11/83) of the control group, the difference between the two groups was statistically significant (P<0.05).Conclusion Phosphate dissolving injection should be used for organophosphorus pesticide poisoning in effect is obvious, which is conducive to promoting the early recovery of patients, and effectively improve the cholinesterase activity, reduce the incidence of adverse reactions.lt has good safety, it is worthy of clinical application.
作者
王灿荣
Wang Canrong(The People s Hospital of Heqing County, Heqing, Yunnan 671500)
出处
《基层医学论坛》
2019年第8期1045-1047,共3页
The Medical Forum
关键词
有机磷农药中毒
急救
解磷注射液
胆碱酯酶活性
不良反应
Organophosphorus pesticide poisoning
First aid
Phosphate dissolving injection
Cholinesterase activity
Adverse reactions
