摘要
目的:利用血清IL-6和IL-8炎症因子表达分析先天性巨结肠相关性小肠结肠炎及其临床价值。方法:选取2016年11月～2017年11月期间在某院就诊的24例HAEC患者作为本次研究的对象,将其设为研究组,选取同期24例体征正常的健康患者作为观察组,使用酶联免疫吸附法检测两组研究对象血清hs-CRP、TNF-α、IL-6、IL-8及IL-10的指标结果,对比两组患者的相关指标水平。结果:研究组的血清hs-CRP、TNF-α、IL-6及IL-8检测结果明显高于观察组,差异有统计学意义(P<0.05);研究组在血清IL-10方面低于观察组,差异有统计学意义(P<0.05)。结论:利用炎症因子检测先天性巨结肠相关性小肠结肠炎操作简单,能够准确反映出患者的病情,对后期的临床治疗起到了重要的评估作用,临床参考价值可观,建议推广使用。
Objective:To analyze the clinical value of serum IL-6 and IL-8 inflammatory factors expression in patients with congenital hirschsprung-colon colic intestinal colitis.Methods:24 patients with HAEC present in a hospital from November 2016 to November 2017 were selected as the subjects of this study and as the study group;24 healthy patients with normal physical signs were selected as the observation group.Enzyme-linked immunosorbent assay(ELISA)was used to detect serum hs-CRP,TNF-α,IL-6,IL-8 and IL-10 levels in two groups of subjects and compared the relevant indicators of the two groups.Results:Serum hs-CRP,TNF-α,IL-6 and IL-8 levels in the study group were significantly higher than those in the observation group(P<0.05).The study group was lower than the observation group in serum IL-10,the difference was statistically significant(P<0.05).Conclusion:Using inflammatory factors on detection of congenital megacolon-associated enterocolitis is simple,it can accurately reflect the patient's condition,and plays an important role in the evaluation of clinical treatment in the later period.The clinical reference value is considerable and it is recommended to promote the use.
作者
严然
Yan Ran(Department of Pathology,Kaifeng Children's Hospital,Kaifeng 475000)
出处
《数理医药学杂志》
2019年第2期206-207,共2页
Journal of Mathematical Medicine
关键词
先天性巨结肠
炎症因子
小肠结肠炎
congenital megacolon
inflammatory factor
enterocolitis
