摘要
随着新一代测序技术的发展,肠道菌群与人体各个疾病的关系受到学者们广泛关注,肠道菌群失调与类风湿关节炎(RA)、糖尿病、炎症性肠病等自身免疫性疾病有关。恢复正常肠道菌群可能阻止RA进展,甚至改善其症状。传统抗风湿药因其可能存在明显药物不良反应或部分RA患者对药物疗效不显著,使得大部分患者病情不能完全缓解,故RA的治疗受到一定限制。目前,关于RA治疗的新方法仍在不断探索中,未来调节肠道正常菌群将为RA的治疗带来新思路。
With the development of a new generation of gene sequencing technology,the relationship between intestinal flora and various diseases of the human body has been extensively concerned by scholars.The intestinal flora imbalance is associated with autoimmune diseases,such as rheumatoid arthritis(RA),diabetes and inflammatory bowel disease and so on.Restoring normal intestinal flora may prevent RA progression and even improve the symptoms.Traditional anti-rheumatic drugs may have obvious adverse drug reactions and no significant effect in some patients,which results in the incomplete alleviation of most patietns,so the treatment of RA is limited.At present,new methods for the treatment of RA are still being explored,and regulating the intestinal flora will bring new ideas in the future.
作者
刘雪梅
于泓
LIU Xuemei;YU Hong(Department of Nephrology and Rheumatology, Affiliated Hospital of Zunyi Medical University,Zunyi 563000,China)
出处
《医学综述》
2019年第4期711-715,721,共6页
Medical Recapitulate
基金
贵州省高校工程技术研究中心建设项目(黔教合KY字〔2012〕022号)
关键词
类风湿关节炎
肠道菌群
粪便菌群移植
益生菌
柳氮磺吡啶
二甲双胍
Rheumatoid arthritis
Intestinal flora
Faecal microbiota transplantation
Probiotics
Sulfasalazine
Metformin
