摘要
目的探讨细胞角蛋白7(cytokeratin 7, CK7)在慢性肝病肝硬化诊断中的作用。方法回顾性分析2014年1月至2018年5月首都医科大学附属北京佑安医院病理科行肝脏病理检查的病例。本研究纳入病例802例,男性563例,女性239例,平均年龄(51±11)岁。分析不同疾病并发肝硬化时肝组织病理CK7免疫组织化学染色阳性表达比率的不同。结果肝组织CK7阴性表达患者中男性比率较大,而肝组织CK7阳性表达患者中女性比率较CK7阴性患者高。肝硬化肝组织CK7免疫组织化学染色表达阴性的病例年龄较CK7阳性病例大。非病毒性肝硬化肝组织CK7免疫组织化学染色阳性率较病毒性肝硬化组高。与慢性乙型肝炎肝硬化和自身免疫性肝炎引起的肝硬化相比,原发性胆汁性胆管炎(Primary Biliary Cholangitis, PBC)肝硬化患者CK7肝组织阳性表达率明显增加。结论 CK7免疫组织化学染色在区分病毒性和非病毒性肝硬化中发挥一定的指导价值。CK7对于鉴别PBC与自身免疫性肝炎和慢性乙型肝炎肝硬化具有重要作用。
Objective To explore the role of Cytokeratin 7(CK7)in the pathological diagnosis of liver cirrhosis.Methods A retrospective analysis was performed on the liver pathology of the Department of Pathology,Beijing You'an Hospital,Capital Medical University,from January 2014 to May 2018.This study included 802 cases,563 males and 239 females,with an average age of(51±11)years.The positive expression ratio of CK7 immunohistochemical staining in liver tissue pathology was analyzed when different diseases were complicated by cirrhosis.Results The proportion of males with negative expression of CK7 in liver tissue was larger,while the proportion of females with positive expression of CK7 in liver tissue was higher than that of CK7 negative patients.The average age of CK7 immunohistochemical staining in liver cirrhosis liver tissue was larger than that of CK7 positive cases.The positive rate of CK7 immunohistochemical staining in non-viral cirrhosis liver tissue was higher than that in viral cirrhosis group.Compared with chronic hepatitis B cirrhosis and autoimmune hepatitis cirrhosis,the positive rate of CK7 in liver tissue of patients with PBC cirrhosis was significantly increased.Conclusion CK7 immunohistochemical staining has a certain guiding value in distinguishing between viral and non-viral cirrhosis.CK7 plays an important role in the identification of PBC and autoimmune hepatitis and hepatitis B cirrhosis.
作者
王彦坤
马俊骥
张明
Wang Yankun;Ma Junji;Zhang Ming(Department of Pathology,Beijing You′an Hospital,Capital Medical University,Beijing 100069,China;Department of Gastroenterology,the Second Hospital of Hebei Medical University,Hebei Key Laboratoryof Gastroenterology,Hebei Institute of Gastroenterology,Shijiazhuang 050000,China)
出处
《临床荟萃》
CAS
2019年第2期124-127,共4页
Clinical Focus
基金
河北省自然科学基金资助项目--RKIP对肝纤维化小鼠肝脏细胞外基质的影响及作用机制(H2015206431)
关键词
肝硬化
肝脏病理
肝炎
病毒性
人
胆管炎
肝炎
自身免疫性
liver cirrhosis
liver pathology
hepatitis,viral,human
cholangitis
hepatitis,autoimmune
