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HIV相关性周围神经病诊治进展 被引量:2

Progress in diagnosis and treatment of HIV peripheral neuropathy
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摘要 周围神经病是人类免疫缺陷病毒(human immunodeficiency virus, HIV)感染者最常见的神经系统疾病,临床表现以远端对称性周围神经病、急性炎症性脱髓鞘性多发性神经病或慢性炎症性脱髓鞘性多发性神经病及多发性单神经病最为常见,严重影响患者的生活质量。本文旨在通过分析HIV相关性周围神经病(HIV peripheral neuropathy,HIV-PN)的病理生理变化及发病机制,深入了解HIV-PN的临床表现,总结其诊治经验,从而指导临床医师正确认识、合理预防、规范诊治该病。 Peripheral neuropathy is the most common neurological disease in HIV-infected people.Distal symmetrical peripheral neuropathy,acute inflammatory demyelinating polyneuropathy,chronic inflammatory demyelinating polyneuropathy and mononeuropathy multiplex are the most common clinical complications,which seriously affect life quality of patients.This article aims to analyze the pathophysiological changes and pathogenesis of HIV peripheral neuropathy(HIV-PN),to understand the clinical manifestations of HIV-PN,and to summarize its experience in diagnosis and treatment,so as to guide clinicians to correctly understand,reasonable prevent the disease,and standardize the diagnosis and treatment.
作者 孙柳青 崔芳 黄德晖 Sun Liuqing;Cui Fang;Huang Dehui(Department of Neurology,Hainan Hospital,PLA General Hospital,Sanya 572013,China)
出处 《临床荟萃》 CAS 2019年第2期106-110,共5页 Clinical Focus
关键词 周围神经系统疾病 获得性免疫缺陷综合征 诊断 治疗 peripheral nervous system diseases acquired immunodeficiency syndrome diagnosis treatment
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  • 1Yan Cui,Cynthia X.Shi,Zunyou Wu.Epidemiology of HIV/AIDS in China: recent trends[J].Global Health Journal,2017,1(1):26-32. 被引量:7
  • 2McArthur JC, Hoover DR, Bacellar H, et al. Dementia in AIDS patients:incidence and risk factors. Multicenter AIDS Cohort Study[J]. Neurology, 1993,43 (11) : 2245-2252.
  • 3Dreyer EB, Kaiser PK, Offermann JT, et al. HIV- 1 coat protein neurotoxicity prevented by calcium channel antagonists [J]. Science, 1990,248(4953):364 367.
  • 4Bagetta G,Corasaniti MT,Malorni W,et al. The HIV-1 gp120 causes ultrastructural changes typical of apoptosis in the rat cerebral cortex[J]. Neuroreport,1996,7( 11 ) : 1722-1724.
  • 5Lopez CD, Ao Y, Rohde LH, et al. Proapoptotic p53-interacting protein 53BP2 is induced by UV irradiation but suppressed by p53[J]. Mol Cell Biol,2000,20(21) :8018-8025.
  • 6Meucci O, Fatatis A, Simen AA, et al. Chemokines regulate hippocampal neuronal signaling and gp120 neurotoxicity [ J ]. Proc Natl Acad Sci U S A,1998,95(24):14500-14505.
  • 7Barre Sinoussi F,Chermann JC, Rey F, et al. Isolation of a T-lymphotropie retrovirus from a patient at risk for acquired immune deficiency syndrome (AIDS) [J]. Science, 1983,220 (4599):868-871.
  • 8Brenneman DE, Westbrook GL, Fitzgerald SP, et al. Neuronal cell killing by the envelope protein of HIV and its prevention by vasoaetive intestinal peptide[J]. Nature, 1988,335 ( 6191 ) : 639-642.
  • 9Bachis A, Biggio F, Major EO, et al. M- and T-tropic HIVs promote apoptosis in rat neurons [J]. J Neuroimmune Pharmacol, 2009,4 ( 1 ): 150-160.
  • 10Kaul M, Ma Q, Medders KE, et al. HIV-1 coreceptors CCR5 and CXCR4 both mediate neuronal cell death but CCR5 paradoxically can also contribute to protection[J]. Cell Death Differ, 2007,14(2) : 296-305.

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