摘要
【目的】探索社区不同年龄段女性端粒长度改变规律及其衰老分值的变化特点。【方法】从南昌市区多家三甲医院和部分社区卫生服务中心健康体检人群中按年龄分层随机抽取20岁以上女性作为研究对象,进行端粒相对长度检测和分析,同时采用《生理-心理-社会三维人体衰老度量表(PPSHAS)》量表测量其衰老分值。【结果】本次研究共获得有效样本406例,不同年龄组的端粒相对长度的差异有统计学意义(P<0.001),端粒相对长度随年龄增加而缩短,端粒长度(Y)与年龄(X)的相关性分析显示呈中高度负相关(r=-0.623,<0.001),回归方程为:Y=-0.012X+1.984(P<0.001,R2=0.400);衰老分值随年龄的增长而增高,且在40～、60～岁组有明显上升趋势,端粒相对长度则有明显下降趋势,提示两者有一定的契合度,衰老分值有助于对女性衰老的深入研究。【结论】健康女性外周血白细胞端粒长度随年龄增加而缩短,端粒相对长度与年龄呈中高度负相关,各年龄组端粒长度差异不同,端粒相对长度与衰老分值在40～、60～岁组的变化趋势提示了女性在该阶段快速衰老,为女性老年问题的研究提供参考。
【Objective】To explore the changing rules of telomere length and the scores trend in different aging groups of women.【Methods】The 20-year-old and above healthy women were randomly selected from several hospitals of Nanchang University.Peripheral blood samples were collected as test samples,relative length of telomere was detected and analyzed.Meanwhile,the aging score was measured by PPSHAS scale.【Results】A total of 406 effective samples were obtained in this study,and the difference of telomere relative length in different age groups was statistically significant(P<0.001).The results showed that the relative length of telomere shortened with age,there is a highly negative correlation between telomere length(Y)and age(X;r=-0.623,P<0.001).The regression equation is Y=-0.012X+1.984(P<0.001,R2=0.400).Scores increased with age,and there was a distinct upward trend in 40~and 60~years old groups.The relative length of telomere decreased significantly,suggesting that there was a certain degree of agreement between them.Scores contributed to further research on female senescence.【Conclusion】The telomere length of peripheral blood leukocytes in healthy women is shortened with age,and the relative length of telomere is negatively correlated with age.The change trend of telomere length and senescence score in 40~and 60~age groups suggests that women are rapidly aging at this stage and provide reference for the study of women′s elderly problem.
作者
李翔
刘星
何涛
周跃平
魏毓
黄河浪
LI Xiang;LIU Xing;HE Tao;ZHOU Yue-ping;WEI Yu;HUANG He-lang(Jiangxi Province Key Laboratory of Preventive Medicine,Nanchang University,Nanchang 330006,China)
出处
《中山大学学报（医学版）》
CAS
CSCD
北大核心
2019年第1期155-160,共6页
Journal of Sun Yat-Sen University:Medical Sciences
基金
国家自然科学基金(81360446
71663037)
